Guo Ruixue, Guo Xinbo, Li Tong, Fu Xiong, Liu Rui Hai
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Food Science, Cornell University, Ithaca, NY 14853, United States.
Food Chem. 2017 Apr 15;221:997-1003. doi: 10.1016/j.foodchem.2016.11.063. Epub 2016 Nov 15.
Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol.
对沙棘（沙棘属）四个亚种的浆果提取物的植物化学特征、抗氧化和抗增殖活性进行了评估和比较。在这些亚种中，中国沙棘亚种表现出最高的总酚含量（38.7±1.3mgGA当量/g干重）以及相应的总抗氧化活性。而云南沙棘亚种的细胞抗氧化和抗增殖活性最高。总抗氧化活性与总酚、异鼠李素-3-芸香糖苷和异鼠李素-3-葡萄糖苷显著相关。植物化学物质的细胞抗氧化活性和抗增殖活性与酚酸和黄酮苷元有相当的相关性。针对人肝癌HepG2细胞增殖研究的单个化合物较低的半数有效剂量（EC）证实了沙棘提取物的抗增殖活性与黄酮苷元（包括异鼠李素、槲皮素和山奈酚）之间有更好的相关性。
