Hayward J C, Gillespie S M, Kaplan K M, Packer R, Pallansch M, Plotkin S, Schonberger L B
Division of Neurology, Children's Hospital of Philadelphia, PA.
Pediatr Infect Dis J. 1989 Sep;8(9):611-6. doi: 10.1097/00006454-198909000-00009.
In the summer of 1987 five children were seen at The Children's Hospital of Philadelphia because of acute onset of flaccid paralysis of an arm or leg(s). Although there were documented exposures to oral poliovirus vaccine and coxsackievirus B3 in some of the cases, the clinical, epidemiologic and laboratory findings indicate that enterovirus 71 was the common etiologic agent for this unusual outbreak of poliomyelitis-like paralysis. Of the five children three recovered completely; the other two had residual paralysis with weakness and muscle wasting. Imaging studies of the spinal cord in the two children with residual paralysis revealed defects in the ventral aspect of the spinal cord. This series of paralytic cases attributed to enterovirus 71 is the largest reported in the United States.
1987年夏天，费城儿童医院接诊了5名儿童，他们均因手臂或腿部突然出现弛缓性麻痹前来就医。尽管部分病例有口服脊髓灰质炎疫苗及B3型柯萨奇病毒暴露史，但临床、流行病学及实验室检查结果表明，肠道病毒71型是此次不寻常的类脊髓灰质炎麻痹暴发的常见病原体。5名儿童中，3名完全康复；另外两名有残留麻痹，伴有肌无力和肌肉萎缩。对两名残留麻痹儿童的脊髓进行影像学检查，发现脊髓腹侧有缺损。这一系列由肠道病毒71型引起的麻痹病例是美国报告的此类病例中数量最多的。
