Kim Eunsol, Tae Giyoong
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005 Republic of Korea.
Biomater Res. 2016 Dec 7;20:39. doi: 10.1186/s40824-016-0086-y. eCollection 2016.
Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the patient specific treatment in regenerative medicine. Overexpression of diverse factors such as general reprogramming factors or lineage specific transcription factors can change the fate of already differentiated cells. On the other hand, biomaterials can provide physical and topographical cues or biochemical cues on cells, which can dictate or significantly affect the differentiation of stem cells. The role of biomaterials on direct reprogramming has not been elucidated much, but will be potentially significant to improve the efficiency or specificity of direct reprogramming. In this review, the strategies for general direct reprogramming and biomaterials-guided stem cell differentiation are summarized with the addition of the up-to-date progress on biomaterials for direct reprogramming.
直接重编程可改变成熟细胞的命运，是一项近来备受关注的非常有用的技术。这种方法能够消除直接使用干细胞的弊端，并允许在再生医学中进行针对患者的个性化治疗。多种因子的过表达，如一般重编程因子或谱系特异性转录因子，可改变已分化细胞的命运。另一方面，生物材料能够为细胞提供物理和拓扑学线索或生化线索，这些线索可决定或显著影响干细胞的分化。生物材料在直接重编程中的作用尚未得到充分阐明，但对于提高直接重编程的效率或特异性可能具有重要意义。在本综述中，总结了一般直接重编程和生物材料引导的干细胞分化策略，并补充了直接重编程生物材料的最新进展。
