Department of Bioengineering , University of California, Los Angeles , Los Angeles , California 90095 , United States.
Department of Medicine , University of California, Los Angeles , Los Angeles , California 90095 , United States.
ACS Nano. 2020 Feb 25;14(2):1296-1318. doi: 10.1021/acsnano.9b04837. Epub 2020 Feb 3.
Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/nanotechnologies can enhance the reprogramming performance and through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.
细胞重编程是一项革命性的生物技术，为再生医学、疾病建模、药物发现等领域的细胞命运和功能工程提供了强大的工具。利用生物材料和微纳技术的进展，可以通过开发传递策略和控制生物物理和生物化学线索来增强重编程性能。在这篇综述中，我们介绍了细胞重编程的最新技术，并强调了利用微纳技术工程生物材料以提高重编程效率和质量的最新突破。最后，我们讨论了重编程技术和临床转化的未来方向和挑战。
