Shetty Rohit, Sethu Swaminathan, Chevour Priyanka, Deshpande Kalyani, Pahuja Natasha, Nagaraja Harsha, Pindipapanahalli Narendra, Ghosh Arkasubhra
Cornea and Refractive Surgery Division, Narayana Nethralaya Eye Hospital, Bangalore, India.
GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India.
Transl Vis Sci Technol. 2016 Dec 14;5(6):16. doi: 10.1167/tvst.5.6.16. eCollection 2016 Dec.
Dry eye is associated with inflammation, pain, and discomfort. Vitamin D is known to modulate immune responses and pain. This study investigates the level of serum vitamin D and tear-inflammatory proteins with relation to exaggerated symptoms in patients with mild dry eye.
Patients with mild dry eye signs (Dry Eye Workshop [DEWS] severity grade 1) but with exaggerated symptoms and healthy controls ( = 19, each) were recruited for this cross-sectional study. Schirmer's Test I (mm), tear film break-up time (TBUT; secs), and ocular surface disease index (OSDI) score were recorded. Serum vitamin D level and tear cytokine levels were measured.
The mean OSDI score in the patient cohort (46 ± 3) was significantly higher than controls (8.4 ± 1.6). TBUT was lower (7.6 ± 0.3 secs) in patients compared with controls (11.0 ± 0.9 secs). Mean Schirmer's Test I value in patients (19.3 ± 1.4 mm) was lower than in controls (30.6 ± 1.9 mm). An inverse correlation was observed between serum vitamin D levels and OSDI score ( = -0.569; = 0.01). Significantly higher levels of interleukin (IL)-17A/F, interferon (IFN)-, monocyte chemotactic protein (MCP)-1, intercellular adhesion molecule (ICAM)-1, IL-4, IL-10, and decreased IL-2 concentrations was observed in the tears of patients compared with controls ( < 0.05).
Decreased serum vitamin D was associated with exaggerated symptoms in dry eye patients with mild dry eye signs. In addition, altered tear cytokine profile was also observed in these patients.
Vitamin D measurements would aid in the diagnosis and management of dry eye.
干眼症与炎症、疼痛和不适相关。已知维生素D可调节免疫反应和疼痛。本研究调查轻度干眼症患者血清维生素D水平和泪液炎症蛋白水平与症状加重之间的关系。
本横断面研究招募了有轻度干眼体征（干眼研讨会[DEWS]严重程度1级）但症状加重的患者和健康对照（每组n = 19）。记录泪液分泌试验I（mm）、泪膜破裂时间（TBUT；秒）和眼表疾病指数（OSDI）评分。测量血清维生素D水平和泪液细胞因子水平。
患者队列的平均OSDI评分为（46 ± 3），显著高于对照组（8.4 ± 1.6）。与对照组（11.0 ± 0.9秒）相比，患者的TBUT较低（平均7.6 ± 0.3秒）。患者的平均泪液分泌试验I值（19.3 ± 1.4 mm）低于对照组（30.6 ± 1.9 mm）。血清维生素D水平与OSDI评分呈负相关（r = -0.569；P = 0.01）。与对照组相比，患者泪液中白细胞介素（IL）-17A/F、干扰素（IFN）-γ、单核细胞趋化蛋白（MCP）-1、细胞间黏附分子（ICAM）-1、IL-4、IL-10水平显著升高，IL-2浓度降低（P < 0.05）。
血清维生素D水平降低与有轻度干眼体征的干眼症患者症状加重有关。此外，这些患者还观察到泪液细胞因子谱改变。
维生素D检测有助于干眼症的诊断和管理。
Zotero 插件
