Wu C-Y, Du S-L, Zhang J, Liang A-L, Liu Y-J
Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Cancer Gene Ther. 2017 Jan;24(1):6-12. doi: 10.1038/cgt.2016.69. Epub 2016 Dec 16.
Exosomes are nanosized vesicles, released by various cells, which have essential roles in intercellular communication locally and systemically through transporting their contents such as proteins and lipids as well as RNA. It was clear that the element of contents in exosomes reassembled with the emerging of cancers. Over the past decade, researchers paid more attention to the role of exosomes in breast cancer. The purpose of this review was to discuss the details of the biological characteristics of exosomes in breast cancer. The discussion would focus on the role of exosomes in breast cancer development, progression, metastasis and drug resistance, as well as related therapeutic and diagnostic strategies.
外泌体是由各种细胞释放的纳米级囊泡，通过运输蛋白质、脂质和RNA等内容物在局部和全身的细胞间通讯中发挥重要作用。很明显，随着癌症的出现，外泌体中的内容物成分发生了重新组合。在过去十年中，研究人员更加关注外泌体在乳腺癌中的作用。本综述的目的是讨论乳腺癌中外泌体生物学特性的细节。讨论将集中在外泌体在乳腺癌发生、发展、转移和耐药性中的作用，以及相关的治疗和诊断策略。
