Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Institute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Sci Rep. 2016 Dec 16;6:39324. doi: 10.1038/srep39324.
Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytokine participating in chronic heart failure (CHF). However, the potential impact of IL-34 in CHF complications remains unknown. In order to determine the clinical significance of serum IL-34 in CHF patients, especially those with kidney dysfunction and coronary artery disease (CAD) comorbid conditions, serum IL-34 was measured in 510 consecutive patients with CHF in a cross-sectional study. The present study demonstrated that higher serum IL-34 levels were associated with poorer renal function and more severe anemia in patients with CHF. After adjusting for age, gender, conventional risk factors, and other significant covariates, IL-34 positively correlated with the presence and severity of renal dysfunction (as measured by eGFR and cystatin C) on multivariable linear and logistic regression analysis. IL-34 was also demonstrated to be an independent risk factor for CAD among HF patients. In conclusion, elevated serum IL-34 levels were demonstrated to be independently associated with renal insufficiency and CAD in patients with CHF, regardless of the systolic function.
在心力衰竭（HF）患者中鉴定出促炎介质，其中一些可能被用作具有诊断或预后价值的生物标志物。白细胞介素 34（IL-34）作为集落刺激因子 1 受体（CSF-1R）的附加配体，已被鉴定为参与慢性心力衰竭（CHF）的促炎细胞因子。然而，IL-34 在 CHF 并发症中的潜在影响尚不清楚。为了确定血清 IL-34 在 CHF 患者中的临床意义，特别是那些伴有肾功能不全和冠状动脉疾病（CAD）合并症的患者，本研究在一项横断面研究中测量了 510 例连续 CHF 患者的血清 IL-34。本研究表明，较高的血清 IL-34 水平与 CHF 患者的肾功能较差和更严重的贫血有关。在校正年龄、性别、常规危险因素和其他重要协变量后，IL-34 与肾功能障碍的存在和严重程度（通过 eGFR 和胱抑素 C 测量）呈正相关，多元线性和逻辑回归分析。IL-34 也是 HF 患者 CAD 的独立危险因素。总之，无论收缩功能如何，升高的血清 IL-34 水平均与 CHF 患者的肾功能不全和 CAD 独立相关。
