Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States.
Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States.
Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):636-644. doi: 10.1016/j.bbagrm.2016.10.012. Epub 2016 Oct 29.
NUCLEAR FACTOR-Y (NF-Y) is a heterotrimeric transcription factor (TF) consisting of evolutionarily distinct NF-YA, NF-YB and NF-YC subunits. The functional NF-Y heterotrimer binds to CCAAT elements in eukaryotic gene promoters and influences their expression. The genome of the model organism Arabidopsis thaliana encodes 10 distinct NF-YA, NF-YB, and NF-YC proteins, allowing for enormous combinatorial and functional diversity. Two decades of research have elucidated the importance of NF-Ys in plant growth, development and stress responses; however, the molecular mechanisms of action remain largely unexplored. Intriguingly, recent evidence suggests that NF-Ys are frequently associated with other groups of TFs, expanding the potential NF-Y combinatorial complexity. Further, information regarding the regulation of individual NF-Y subunits at the transcriptional and post-transcriptional level is beginning to emerge. In this review, we will identify developing trends within the NF-Y field and discuss recent progress towards a better understanding of NF-Y function, molecular action, and regulation in the context of Arabidopsis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
核因子 Y（NF-Y）是一种由进化上不同的 NF-YA、NF-YB 和 NF-YC 亚基组成的异源三聚体转录因子（TF）。功能性 NF-Y 异源三聚体结合真核基因启动子中的 CCAAT 元件，并影响其表达。模式生物拟南芥的基因组编码了 10 种不同的 NF-YA、NF-YB 和 NF-YC 蛋白，允许巨大的组合和功能多样性。二十年的研究已经阐明了 NF-Y 在植物生长、发育和应激反应中的重要性；然而，其作用的分子机制在很大程度上仍未被探索。有趣的是，最近的证据表明，NF-Ys 经常与其他 TF 群体相关联，从而扩展了潜在的 NF-Y 组合复杂性。此外，关于单个 NF-Y 亚基在转录和转录后水平的调控信息也开始出现。在这篇综述中，我们将确定 NF-Y 领域内的发展趋势，并讨论最近在理解拟南芥中 NF-Y 功能、分子作用和调控方面取得的进展。本文是由 Roberto Mantovani 教授编辑的题为“核因子 Y 在发育和疾病中的作用”的特刊的一部分。
