Moldvay Judit, Jackel M, Bogos K, Soltész I, Agócs L, Kovács G, Schaff Zsuzsa
County Hospital of Pulmonology, Törökbálint, Hungary.
Pathol Oncol Res. 2004;10(2):85-8. doi: 10.1007/BF02893461. Epub 2004 Jun 9.
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas. We have examined the expression of TTF-1 in 100 solitary pulmonary nodules. They included 50 stage I peripheral primary bronchial adenocarcinomas (30 men, 20 women, mean age: 60 years) and 50 metastatic pulmonary adenocarcinomas (21 men, 29 women, mean age: 57 years) of different origins, such as breast (13), colon (13), rectum (13), kidney (7), stomach (2), and thyroid gland (2). TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues. In primary bronchial adenocarcinomas we found immunopositivity in 46/50 cases, among them 30 cases showed strong nuclear immunostaining. In four primary adenocarcinoma cases the observed immunopositivity was localized to the cytoplasm. Out of the metastatic adenocarcinomas all but the 2 thyroid cancers were negative. Both thyroid tumors showed strong immunopositivity. Our results confirm that TTF-1 immunohistochemistry is a very sensitive and highly specific method in the differential diagnosis of primary and metastatic lung adenocarcinomas and should be used in the everyday clinical practice.
甲状腺转录因子-1（TTF-1）是肺和甲状腺腺癌的敏感标志物。本研究的目的是确定其在鉴别原发性和转移性肺腺癌中的作用。我们检测了100个孤立性肺结节中TTF-1的表达情况。其中包括50例I期周围型原发性支气管腺癌（男性30例，女性20例，平均年龄60岁）和50例不同来源的转移性肺腺癌（男性21例，女性29例，平均年龄57岁），这些来源包括乳腺（13例）、结肠（13例）、直肠（13例）、肾脏（7例）、胃（2例）和甲状腺（2例）。对福尔马林固定、石蜡包埋的组织进行TTF-1免疫组化检测。在原发性支气管腺癌中，我们发现46/50例呈免疫阳性，其中30例显示强核免疫染色。在4例原发性腺癌病例中，观察到的免疫阳性定位于细胞质。在转移性腺癌中，除2例甲状腺癌外均为阴性。这2例甲状腺肿瘤均显示强免疫阳性。我们的结果证实，TTF-1免疫组化是鉴别原发性和转移性肺腺癌的一种非常敏感且高度特异的方法，应在日常临床实践中使用。
