Adams J G, Trim C M
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Res Vet Sci. 1989 Sep;47(2):164-9.
Five horses were anaesthetised twice with thiopentone sodium, guaifenesin and halothane. The second anaesthesia was 16 days after the first and two days following oral administration of trichlorfon. Heart rate, carotid arterial, pulmonary arterial and right atrial pressures, cardiac output and blood temperature were measured every 15 minutes for 120 minutes. Heart rate, carotid arterial pressure and cardiac output were similar on both occasions. Pulmonary arterial and right atrial pressures were highest during anaesthesia after treatment with trichlorfon when compared with values obtained before treatment. Pulmonary vascular resistance was significantly decreased at four measurement times during anaesthesia after treatment with trichlorfon. All cardiovascular measurements were within ranges accepted as normal for halothane anaesthesia in horses. In a second experiment, four ponies were anaesthetised with xylazine and ketamine on two occasions one week apart. Two ponies received trichlorfon two days before the second anaesthesia. Heart rate, arterial pressure and respiratory rate recorded during anaesthesia were not different in ponies after organophosphate treatment. The time to standing after the second anaesthesia was significantly increased in all ponies.
五匹马用硫喷妥钠、愈创甘油醚和氟烷进行了两次麻醉。第二次麻醉在第一次麻醉16天后且在口服敌百虫两天后进行。在120分钟内每隔15分钟测量心率、颈动脉压、肺动脉压和右心房压、心输出量及体温。两次测量时心率、颈动脉压和心输出量相似。与治疗前测得的值相比，敌百虫治疗后麻醉期间肺动脉压和右心房压最高。敌百虫治疗后麻醉期间在四个测量时间点肺血管阻力显著降低。所有心血管测量值均在马匹氟烷麻醉公认的正常范围内。在第二个实验中，四匹小马用甲苯噻嗪和氯胺酮进行了两次麻醉，间隔一周。两匹小马在第二次麻醉前两天接受了敌百虫治疗。麻醉期间记录的心率、动脉压和呼吸频率在接受有机磷治疗的小马中无差异。第二次麻醉后站立的时间在所有小马中均显著延长。
