Schwegler N, Notter M, Burkard W
Schweiz Rundsch Med Prax. 1989 Aug 22;78(34):897-904.
The efficacy of radiation therapy combined with local hyperthermia is demonstrated by three case studies. Mode of action and problems are discussed and published results reported. Human tumour cells obtained of biopsies from our patients before the onset of treatments were investigated. The short time cell cultures were treated either with hyperthermia or irradiation alone or with combinations under the same conditions as the clinical treatments. We could clearly demonstrate that cell cultures of human origin respond to irradiation or hyperthermia. But the effect was limited and only cultures treated with combined modalities did not relapse. There is hope that mega-voltage radiation complemented with hyperthermia have a similar effect as high-LET-radiation. Side effects have been moderate so far using an extended clinical use.
三项病例研究证明了放射治疗与局部热疗相结合的疗效。讨论了作用方式和问题，并报告了已发表的结果。对从我们患者治疗开始前的活检中获得的人类肿瘤细胞进行了研究。短时间细胞培养物在与临床治疗相同的条件下单独进行热疗或照射，或进行联合治疗。我们可以清楚地证明，源自人类的细胞培养物对照射或热疗有反应。但效果有限，只有接受联合治疗的培养物没有复发。有希望的是，兆伏级放疗辅以热疗具有与高传能线密度放疗类似的效果。到目前为止，在广泛的临床应用中，副作用一直较为温和。
