Moraes Greice G, Reuter Cézane P, Renner Jane D P, Klinger Elisa I, Ferreira Michele B, Mello Elza D DE, Valim Andréia DE M, Burgos Miria S
Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
Physical Education and Health Department, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4201, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
An Acad Bras Cienc. 2016 Oct-Dec;88(4):2331-2339. doi: 10.1590/0001-3765201620160114.
: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention.
: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling.
: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group.
: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.
FTO是一种与脂肪量和肥胖相关的基因，携带rs9939609多态性风险基因型（AA/AT）的儿童和青少年在接受跨学科干预后，其心脏代谢指标的反应可能与携带TT基因型的受试者不同。
样本包括来自巴西南部的36名学童。我们使用DNA定量和实时聚合酶链反应（PCR）进行多态性基因分型。我们测量了人体测量参数（体重指数（BMI）、腰围、臀围、腰臀比、体脂百分比和皮褶厚度总和）、生化参数（血糖、血脂谱、超敏C反应蛋白、尿酸、丙氨酸转氨酶、天冬氨酸转氨酶、胰岛素和脂联素）以及血压。为期4个月的干预包括体育课、营养咨询以及姿势和口腔健康咨询。
干预后，我们未观察到各基因分组（AA、AT和TT）之间存在显著差异。然而，我们观察到AT/AA基因型组的三个参数（腰围、臀围和C反应蛋白）以及TT基因型组的两个参数（臀围和尿酸）有所改善。
在实施干预计划后，肥胖风险基因型携带者（AA/AT）与TT基因型携带者相比，在生化参数、血压和人体测量参数方面未表现出差异。
