Dueweke Jeffrey J, Awan Tariq M, Mendias Christopher L
J Sport Rehabil. 2017 Apr;26(2):171-179. doi: 10.1123/jsr.2016-0107. Epub 2016 Dec 19.
Eccentric-contraction-induced skeletal muscle injuries, included in what is clinically referred to as muscle strains, are among the most common injuries treated in the sports medicine setting. Although patients with mild injuries often fully recover to their preinjury levels, patients who suffer moderate or severe injuries can have a persistent weakness and loss of function that is refractory to rehabilitation exercises and currently available therapeutic interventions. The objectives of this review were to describe the fundamental biophysics of force transmission in muscle and the mechanism of muscle-strain injuries, as well as the cellular and molecular processes that underlie the repair and regeneration of injured muscle tissue. The review also summarizes how commonly used therapeutic modalities affect muscle regeneration and opportunities to further improve our treatment of skeletal muscle strain injuries.
离心收缩引起的骨骼肌损伤，临床称为肌肉拉伤，是运动医学领域治疗的最常见损伤之一。虽然轻度损伤的患者通常能完全恢复到受伤前的水平，但中度或重度损伤的患者可能会持续存在无力和功能丧失的情况，康复锻炼和目前可用的治疗干预措施对此难以奏效。本综述的目的是描述肌肉中力传递的基本生物物理学、肌肉拉伤损伤的机制，以及损伤肌肉组织修复和再生的细胞和分子过程。该综述还总结了常用治疗方式如何影响肌肉再生，以及进一步改善骨骼肌拉伤损伤治疗的机会。
