Gumucio Jonathan P, Sugg Kristoffer B, Mendias Christopher L
Departments of 1Orthopaedic Surgery, 2Molecular and Integrative Physiology, and 3Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, MI.
Exerc Sport Sci Rev. 2015 Apr;43(2):93-9. doi: 10.1249/JES.0000000000000041.
Numerous studies in muscle and tendon have identified a central role of the transforming growth factor-β (TGF-β) superfamily of cytokines in the regulation of extracellular matrix growth and remodeling, protein degradation, and cell proliferation and differentiation. We provide a novel framework for TGF-β and myostatin signaling in controlling the coordinated adaptation of both skeletal muscle and tendon tissue to resistance training.
众多针对肌肉和肌腱的研究已经确定，细胞因子转化生长因子-β（TGF-β）超家族在调节细胞外基质生长与重塑、蛋白质降解以及细胞增殖和分化过程中发挥着核心作用。我们提供了一个新的框架，用于解释TGF-β和肌肉生长抑制素信号在控制骨骼肌和肌腱组织对阻力训练的协同适应性方面的作用。
