Luan Chih-Wei, Yang Hsin-Yi, Tsai Yao-Te, Hsieh Meng-Chiao, Chou Hsin-Hsu, Chen Kuo-Su
Department of Otorhinolaryngology-Head and Neck Surgery, LO-Sheng Hospital Ministry of Health and Welfare-Home, New Taipei City 242, Taiwan.
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Diagnostics (Basel). 2021 Feb 26;11(3):403. doi: 10.3390/diagnostics11030403.
The C-reactive protein-to-albumin ratio is a proven prognostic predictor of nasopharyngeal carcinoma. However, the role of the C-reactive protein-to-albumin ratio in other head and neck cancers remains unclear. This meta-analysis explored the prognostic value of the C-reactive protein-to-albumin ratio in head and neck cancers. A systematic search was conducted. Outcomes of interest included overall survival, disease-free survival, and distant metastasis-free survival. The hazard ratio with 95% confidence interval was pooled using a random-effects model. A total of 11 publications from the literature were included, allowing for the analysis of 7080 participants. Data pooling demonstrated that pretreatment C-reactive protein-to-albumin ratio had a hazard ratio of 1.88 (95% CI: 1.49-2.37, < 0.001) for predicting overall survival, 1.91 (95% CI: 1.18-3.08, = 0.002) for disease-free survival, and 1.46 (95% CI: 1.08-1.96, = 0.001) for distant metastasis-free survival. Subgroup analysis showed that the C-reactive protein-to-albumin ratio is a significant prognostic marker for various head and neck cancers. An elevated pretreatment C-reactive protein-to-albumin ratio predicts a worse prognosis for patients with head and neck cancers. Therefore, the C-reactive protein-to-albumin ratio could serve as a potential prognostic biomarker facilitating treatment stratification.
C反应蛋白与白蛋白比值是鼻咽癌已被证实的预后预测指标。然而，C反应蛋白与白蛋白比值在其他头颈部癌症中的作用仍不明确。这项荟萃分析探讨了C反应蛋白与白蛋白比值在头颈部癌症中的预后价值。进行了系统检索。感兴趣的结局包括总生存期、无病生存期和无远处转移生存期。采用随机效应模型汇总95%置信区间的风险比。共纳入11篇文献，纳入7080名参与者进行分析。数据汇总表明，治疗前C反应蛋白与白蛋白比值预测总生存期的风险比为1.88（95%CI：1.49-2.37，P<0.001），预测无病生存期的风险比为1.91（95%CI：1.18-3.08，P=0.002），预测无远处转移生存期的风险比为1.46（95%CI：1.08-1.96，P=0.001）。亚组分析表明，C反应蛋白与白蛋白比值是各种头颈部癌症的重要预后标志物。治疗前C反应蛋白与白蛋白比值升高预示着头颈部癌症患者预后较差。因此，C反应蛋白与白蛋白比值可作为一种潜在的预后生物标志物，有助于治疗分层。
