Babrawala Irfana, Munivenkatappa Lakshmaiah Venkatesh Prabhuji, Bangalore Varadhan Karthikeyan
Chin J Dent Res. 2016;19(4):231-237. doi: 10.3290/j.cjdr.a37148.
To evaluate the effectiveness of 15% chitosan in gel form as a periodontal regenerative material in the periodontal intrabony defects.
A pilot study split-mouth design of 10 patients within the age group of 30 to 55 years with bilateral intrabony defects ≥ 3mm and clinical attachment levels (CAL) ≥ 5mm were selected. The test site received open flap debridement with 15% Chitosan gel as a regenerative material and the controlateral side that acted as a control received only open flap debridement. Clinical and radiographic measurements were recorded at baseline, and 3, 6 and 9 months after the treatment.
Data revealed that there was a significant improvement in both clinical and radiographic parameters when intragroup comparison was performed. When intergroup comparison was done, there was a mean difference in CAL (5.8 ± 1.398 mm) and the depth of the intrabony defect (3.41 ± 1.17 mm) at 9 months when compared to baseline.
Within the limitations of the study, it can be concluded that a 15% concentration of chitosan gel is a promising aid and could be used as an effective material in periodontal regeneration.
评估凝胶形式的15%壳聚糖作为牙周骨内缺损牙周再生材料的有效性。
选取10例年龄在30至55岁之间、双侧骨内缺损≥3mm且临床附着水平（CAL）≥5mm的患者进行一项试点研究的分口设计。试验部位接受开放性翻瓣清创术，使用15%壳聚糖凝胶作为再生材料，而作为对照的对侧仅接受开放性翻瓣清创术。在基线以及治疗后3、6和9个月记录临床和影像学测量结果。
数据显示，进行组内比较时，临床和影像学参数均有显著改善。进行组间比较时，与基线相比，9个月时CAL的平均差异为（5.8±1.398mm），骨内缺损深度的平均差异为（3.41±1.17mm）。
在本研究的局限性范围内，可以得出结论，15%浓度的壳聚糖凝胶是一种有前景的辅助材料，可作为牙周再生的有效材料。
