Son Jeong-Whan, Lee Min Sun, Lee Jae Sung
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-744, Korea.
Phys Med Biol. 2017 Jan 21;62(2):465-483. doi: 10.1088/1361-6560/aa5076. Epub 2016 Dec 21.
Positron emission tomography (PET) detectors with the ability to encode depth-of-interaction (DOI) information allow us to simultaneously improve the spatial resolution and sensitivity of PET scanners. In this study, we propose a DOI PET detector based on a stair-pattern reflector arrangement inserted between pixelated crystals and a single-ended scintillation light readout. The main advantage of the proposed method is its simplicity; DOI information is decoded from a flood map and the data can be simply acquired by using a single-ended readout system. Another potential advantage is that the two-step DOI detectors can provide the largest peak position distance in a flood map because two-dimensional peak positions can be evenly distributed. We conducted a Monte Carlo simulation and obtained flood maps. Then, we conducted experimental studies using two-step DOI arrays of 5 × 5 LuYSiO:Ce crystals with a cross-section of 1.7 × 1.7 mm and different detector configurations: an unpolished single-layer (S) array, a polished single-layer (S) array and a polished stacked two-layer (T) array. For each detector configuration, both air gaps and room-temperature vulcanization (RTV) silicone gaps were tested. Detectors S and T showed good peak separation in each scintillator with an average peak-to-valley ratio (PVR) and distance-to-width ratio (DWR) of 2.09 and 1.53, respectively. Detector S showed lower PVR and DWR (1.65 and 1.34, respectively). The configuration of detector T is preferable for the construction of time-of-flight-DOI detectors because timing resolution was degraded by only about 40 ps compared with that of a non-DOI detector. The performance of detectors S and S was lower than that of a non-DOI detector, and thus these designs are favorable when the manufacturing cost is more important than timing performance. The results demonstrate that the proposed DOI-encoding method is a promising candidate for PET scanners that require high resolution and sensitivity and operate with conventional acquisition systems.
具备编码相互作用深度(DOI)信息能力的正电子发射断层扫描(PET)探测器,使我们能够同时提高PET扫描仪的空间分辨率和灵敏度。在本研究中,我们提出了一种基于插入像素化晶体之间的阶梯图案反射器排列和单端闪烁光读出的DOI PET探测器。该方法的主要优点是其简单性;DOI信息从泛洪图中解码,并且数据可以通过使用单端读出系统简单地获取。另一个潜在优点是,两步DOI探测器可以在泛洪图中提供最大的峰值位置距离,因为二维峰值位置可以均匀分布。我们进行了蒙特卡罗模拟并获得了泛洪图。然后,我们使用5×5的LuYSiO:Ce晶体的两步DOI阵列进行了实验研究,该晶体的横截面为1.7×1.7毫米,并且具有不同的探测器配置:未抛光的单层(S)阵列、抛光的单层(S)阵列和抛光的堆叠双层(T)阵列。对于每种探测器配置,都测试了气隙和室温硫化(RTV)硅胶间隙。探测器S和T在每个闪烁体中都显示出良好的峰值分离,平均峰谷比(PVR)和距离与宽度比(DWR)分别为2.09和1.53。探测器S显示出较低的PVR和DWR(分别为1.65和1.34)。探测器T的配置对于飞行时间-DOI探测器的构建是优选的,因为与非DOI探测器相比,定时分辨率仅降低了约40 ps。探测器S和S的性能低于非DOI探测器,因此当制造成本比定时性能更重要时,这些设计是有利的。结果表明,所提出的DOI编码方法对于需要高分辨率和灵敏度并使用传统采集系统运行的PET扫描仪是一个有前途的候选方案。