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Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using an Air- and Moisture-Stable Iron Racemization Catalyst.

作者信息

Gustafson Karl P J, Guðmundsson Arnar, Lewis Kayla, Bäckvall Jan-E

机构信息

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.

出版信息

Chemistry. 2017 Jan 23;23(5):1048-1051. doi: 10.1002/chem.201605754. Epub 2017 Jan 16.

DOI:10.1002/chem.201605754
PMID:28005307
Abstract

Herein, we report on a metalloenzymatic dynamic kinetic resolution of sec-alcohols employing an iron-based racemization catalyst together with a lipase. The iron catalyst was evaluated in racemization and then used in dynamic kinetic resolution of a number of sec-alcohols to give enantiomerically pure products in good to high yields. The iron catalyst is air and moisture stable and is readily accessible.

摘要

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