毛冬青根中具有抗血小板聚集活性的三萜类化合物。
Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens.
作者信息
Tan Qinglong, Qiu Maosong, Cao Di, Xiong Tianqin, Zhang Lei, Zhou Lian, Rong Li, Zhou Jinsong, Jin Jing, Zhao Zhongxiang
机构信息
School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
Second affiliation hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
Planta Med. 2017 Jun;83(9):797-804. doi: 10.1055/s-0042-123708. Epub 2016 Dec 22.
Two new triterpenes and five new triterpene saponins, named ilexpusons A-G (-), as well as eight known compounds were isolated from . The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, H-NMR, C-NMR, H-H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds - against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds, , and exhibited significant inhibition of platelet aggregation .
从……中分离出两种新的三萜类化合物和五种新的三萜皂苷，分别命名为冬青皂苷A - G (-)，以及八种已知化合物。通过化学和光谱方法相结合确定了新化合物的结构，包括高分辨电喷雾电离质谱（HRESIMS）、氢核磁共振（H-NMR）、碳核磁共振（C-NMR）、氢-氢化学位移相关谱（H-H COSY）、异核单量子相干谱（HSQC）、异核多键相关谱（HMBC）和核Overhauser效应谱（NOESY）。此外，还测定了化合物 - 对兔血浆中腺苷二磷酸诱导的血小板聚集的生物活性。在所测试的化合物中， 、 和 对血小板聚集表现出显著抑制作用。
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