Li Min, Hu Xiaolan, Huang Jiangtao, Tan Yuan, Yang Baoping, Tang Zhenyu
Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Anaesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
J Am Heart Assoc. 2016 Dec 22;5(12):e004703. doi: 10.1161/JAHA.116.004703.
Considerable controversy exists on the association between retinal vein occlusion (RVO) and stroke risk. Therefore, we conducted a meta-analysis to assess the relationship between RVO and stroke risk.
PubMed, EMBASE, and the Cochrane library databases were searched for cohort studies with data on RVO and stroke risk. Studies that reported adjusted relative risks (RRs) with 95% CIs of stroke associated with RVO were included. Stratified analyses were conducted according to key characteristics. A total of 5 articles including results from 6 prospective cohort studies with 431 cases of stroke and 37 471 participants were included in the meta-analysis. Overall, after adjustment for established cardiovascular risk factors, participants with RVO at baseline were considerably more associated with a greater incidence of stroke risk (combined RR: 1.50, 95% CI: 1.19-1.90), compared to participants without RVO. The results were more pronounced for stroke (RR: 1.72, 95% CI: 1.24-2.37) in the stratified with a stroke history. The risk of stroke was nonsignificant in male subjects (RR: 1.20, 95% CI: 0.96-1.49) and in female subjects (RR: 0.93, 95% CI: 0.64-1.34). The presence of both central RVO (RR: 1.90, 95% CI: 1.46-2.48) and branch RVO (RR: 1.79, 95% CI: 1.18-2.72) was associated with increased risk of stroke. Stratifying by age, the associations between RVO and risk of stroke were similar between the age range in the cohorts that ranged from 50 to 59 years and 60 to 69 years.
Exposure to RVO was associated with an increased risk of stroke, especially in subjects aged between 50 and 69 years. Future studies on the effect of RVO treatment and modifiable risk factor reduction on stroke risk in RVO patients are warranted.
视网膜静脉阻塞（RVO）与中风风险之间的关联存在相当大的争议。因此，我们进行了一项荟萃分析以评估RVO与中风风险之间的关系。
检索了PubMed、EMBASE和Cochrane图书馆数据库，查找有关RVO和中风风险数据的队列研究。纳入报告了RVO相关中风的校正相对风险（RR）及95%置信区间（CI）的研究。根据关键特征进行分层分析。荟萃分析共纳入5篇文章，这些文章包含6项前瞻性队列研究的结果，涉及431例中风病例和37471名参与者。总体而言，在对已确定的心血管危险因素进行校正后，与无RVO的参与者相比，基线时患有RVO的参与者发生中风风险的几率显著更高（合并RR：1.50，95%CI：1.19 - 1.90）。在有中风病史的分层中，中风结果更为显著（RR：1.72，95%CI：1.24 - 2.37）。中风风险在男性受试者（RR：1.20，95%CI：0.96 - 1.49）和女性受试者（RR：0.93，95%CI：0.64 - 1.34）中无统计学意义。中央RVO（RR：1.90，95%CI：1.46 - 2.48）和分支RVO（RR：1.79，95%CI：1.18 - 2.72）的存在均与中风风险增加相关。按年龄分层，在队列年龄范围为50至59岁和60至69岁的人群中，RVO与中风风险之间的关联相似。
暴露于RVO与中风风险增加相关，尤其是在年龄介于50至69岁的人群中。有必要进一步开展关于RVO治疗效果以及降低可改变危险因素对RVO患者中风风险影响的研究。
