Department of Radiology, Hyogo Brain and Heart Center at Himeji, Himeji, Japan.
Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
J Nucl Cardiol. 2018 Jun;25(3):947-954. doi: 10.1007/s12350-016-0749-z. Epub 2016 Dec 22.
We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT).
The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation. We calculated an optimal thallium-201 dose that resulted in better LV myocardial counts during 6 minutes of acquisition time. We corrected the respective values according to the patient's age, sex, body mass index (BMI), and type of stress test. The lowest thallium-201 dose for obtaining acceptable imaging was 1.2 million counts. Radiopharmaceutical doses showed a positive correlation with the patient's age (P < .001), sex (P = .012), BMI (P < .001), and type of stress test (P < .001). Multivariate analysis revealed that the patient's BMI and the type of stress test were statistically significant factors for determining the correct radiopharmaceutical dose (P < .001 for both).
For clinical use of the CZT SPECT system, the optimal individual thallium-201 doses can be determined based on the patient's BMI and type of stress test.
我们旨在使用新型超快心脏伽马相机和碲锌镉（CZT）固态半导体探测器（D-SPECT）确定氯化铊 201 （铊 201）的最佳剂量。
通过对模型进行研究，确定获得左心室（LV）心肌计数的最佳铊 201 剂量。连续 292 例患者进行铊 201 注射的应激心肌灌注成像。应激试验包括运动或药物（腺苷）激发。我们计算出在 6 分钟的采集时间内获得更好的 LV 心肌计数的最佳铊 201 剂量。我们根据患者的年龄、性别、体重指数（BMI）和应激试验类型对相应的值进行了校正。获得可接受成像的最低铊 201 剂量为 120 万计数。放射性药物剂量与患者的年龄（P <.001）、性别（P =.012）、BMI（P <.001）和应激试验类型呈正相关（P <.001）。多变量分析显示，患者的 BMI 和应激试验类型是确定正确放射性药物剂量的统计学上显著因素（两者均为 P <.001）。
对于 CZT SPECT 系统的临床应用，可以根据患者的 BMI 和应激试验类型确定最佳的个体铊 201 剂量。
