Gomes Aline Corado, de Sousa Rávila Graziany Machado, Botelho Patrícia Borges, Gomes Tatyanne Letícia Nogueira, Prada Patrícia Oliveira, Mota João Felipe
Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
School of Applied Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
Obesity (Silver Spring). 2017 Jan;25(1):30-38. doi: 10.1002/oby.21671.
To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
Women who had excess weight or obesity were recruited to a randomized, double-blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 10 colony-forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual-energy X-ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin-6, interleukin-10, tumor necrosis factor-α, adiponectin, and the antioxidant enzymes activities were analyzed.
In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (-3.40% vs. -5.48%, P = 0.03), waist-height ratio (-3.27% vs. -5.00%, P = 0.02), conicity index (-2.43% vs. -4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. -18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (-16.67% vs. 15.62%, P < 0.01).
Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.
研究与单独的饮食干预相比，益生菌混合物对身体成分、血脂谱、内毒素血症、炎症和抗氧化谱是否有额外影响。
招募超重或肥胖女性参与一项随机双盲试验，给予她们益生菌混合物（嗜酸乳杆菌和干酪乳杆菌；乳酸乳球菌；双歧双歧杆菌和乳酸双歧杆菌；2×10菌落形成单位/天）（n = 21）或安慰剂（n = 22），为期8周。两组均接受饮食处方。通过人体测量和双能X线吸收法评估身体成分。分析血脂谱、脂质蓄积产物、血浆脂肪酸、脂多糖、白细胞介素-6、白细胞介素-10、肿瘤坏死因子-α、脂联素和抗氧化酶活性。
与饮食干预组相比，饮食干预+益生菌混合物组的腰围（-3.40%对-5.48%，P = 0.03）、腰高比（-3.27%对-5.00%，P = 0.02）、锥度指数（-2.43%对-4.09%，P = 0.03）和血浆多不饱和脂肪酸（5.65%对-18.63%，P = 0.04）下降幅度更大，谷胱甘肽过氧化物酶活性增加（-16.67%对15.62%，P < 0.01）。
补充益生菌混合物比单独的饮食干预更有效地减少腹部肥胖并提高抗氧化酶活性。
