Barnes R M, Harvey M M, Blears J, Finn R, Johnson P M
Int Arch Allergy Appl Immunol. 1986;81(2):141-7. doi: 10.1159/000234123.
Serum IgG antibodies reactive with different dietary proteins have been detected in a significant proportion of adult patients with coeliac disease, dermatitis herpetiformis and atopic eczema. Serum anti-milk antibodies were shown to be distributed predominantly between the IgG2 and IgG4 subclasses, whereas anti-gliadin antibodies in atopic eczema were predominantly of the IgG4 subclass. Furthermore, as antibodies to each of these dietary antigens in healthy adults were markedly restricted to the IgG4 subclass, their production may be part of a normal immune response to dietary proteins. There was no correlation between serum IgG4 antibody and total serum IgG4 level. In contrast, restricted IgG4 anti-gliadin antibodies were less prevalent in the serum of patients with coeliac disease and dermatitis herpetiformis, suggesting defective downstream switching of Ig heavy-chain genes in these conditions.
在相当一部分患有乳糜泻、疱疹样皮炎和特应性皮炎的成年患者中，已检测到与不同饮食蛋白发生反应的血清IgG抗体。血清抗牛奶抗体主要分布在IgG2和IgG4亚类之间，而特应性皮炎中的抗麦醇溶蛋白抗体主要为IgG4亚类。此外，由于健康成年人中针对每种这些饮食抗原的抗体明显局限于IgG4亚类，它们的产生可能是对饮食蛋白正常免疫反应的一部分。血清IgG4抗体与血清总IgG4水平之间没有相关性。相比之下，受限的IgG4抗麦醇溶蛋白抗体在乳糜泻和疱疹样皮炎患者的血清中不太常见，这表明在这些情况下Ig重链基因的下游转换存在缺陷。
