Dunn C J, Schaub R G, Fleming W E, Gibbons A J
Department of Hypersensitivity Diseases Research, Upjohn Company, MI Kalamazoo, MI 49001.
Agents Actions. 1989 Jun;27(3-4):287-9. doi: 10.1007/BF01972800.
Ethylene vinyl acetate (EVA) discs containing either 50 U interleukin-1 (IL-1) or 250 mg bovine serum albumin as control were implanted around the exposed jugular veins of rabbits. After 24 hr, the veins were examined by scanning electron-microscopy. Compared with minor changes in control vein lumena, those of EVA-IL-1 treated veins showed extensive endothelial cell denudation and exposure of basement membrane associated with platelet accumulation and adherence/subendothelial migration of leucocytes. These observations suggest that locally-released IL-1 provokes significant vascular pathological changes "in vivo" and emphasise the importance of this cytokine as a mediator of inflammatory and thrombotic/atherosclerotic diseases.
将含有50单位白细胞介素-1（IL-1）或250毫克牛血清白蛋白作为对照的乙烯-醋酸乙烯酯（EVA）圆盘植入兔暴露的颈静脉周围。24小时后，通过扫描电子显微镜检查静脉。与对照静脉管腔的微小变化相比，EVA-IL-1处理的静脉管腔显示出广泛的内皮细胞剥脱以及基底膜暴露，伴有血小板聚集以及白细胞的黏附/内皮下迁移。这些观察结果表明，局部释放的IL-1在“体内”引发显著的血管病理变化，并强调了这种细胞因子作为炎症和血栓形成/动脉粥样硬化疾病介质的重要性。
