人干扰素的无细胞从头合成。
De novo cell-free synthesis of human interferon.
作者信息
Pestka S, McInnes J, Weiss D, Havell E A, Vilcek J
出版信息
Ann N Y Acad Sci. 1977 Mar 4;284:697-702. doi: 10.1111/j.1749-6632.1977.tb22005.x.
Abstract
Biologically active human interferon was synthesized de novo in a cell-free mouse extract stimulated with messenger RNA from induced human fibroblasts. The identity of the antiviral activity as human interferon was demonstrated by its antigenic and species specificity. Some characteristics of the cell-free synthesis were described.
摘要
具有生物活性的人干扰素是在由来自诱导的人成纤维细胞的信使核糖核酸刺激的无细胞小鼠提取物中重新合成的。通过其抗原性和种属特异性证明了该抗病毒活性为人干扰素。描述了无细胞合成的一些特性。
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