通过在无细胞系统中翻译其信使核糖核酸来进行小鼠干扰素的生物合成。
Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.
作者信息
Thang M N, Thang D C, De Maeyer E, Montagnier L
出版信息
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3975-7. doi: 10.1073/pnas.72.10.3975.
Abstract
A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cells; (2) its antiviral activity was species specific; (3) its activity was completely neutralized by mouse anti-interferon serum. The synthesis of interferon in this cell-free system requires the presence of spermine.
摘要
一小部分含有编码小鼠干扰素信使核糖核酸的小鼠核糖核酸在小麦胚芽系统中高效翻译为一种完全有活性的产物。该产物符合小鼠干扰素的标准，即：（1）它在小鼠细胞中对水疱性口炎病毒和单纯疱疹病毒有活性；（2）其抗病毒活性具有种属特异性；（3）其活性被小鼠抗干扰素血清完全中和。在这个无细胞系统中干扰素的合成需要精胺的存在。
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Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.通过在无细胞系统中翻译其信使核糖核酸来进行小鼠干扰素的生物合成。
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Nucleic Acids Res. 1974 Nov;1(11):1385-97. doi: 10.1093/nar/1.11.1385.
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Proc Natl Acad Sci U S A. 1972 May;69(5):1203-7. doi: 10.1073/pnas.69.5.1203.
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Tobacco mosaic virus RNA directs the synthesis of a coat protein peptide in a cell-free system from wheat.烟草花叶病毒核糖核酸在来自小麦的无细胞系统中指导外壳蛋白肽的合成。
J Mol Biol. 1973 Nov 15;80(4):733-42. doi: 10.1016/0022-2836(73)90206-4.
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Translation of virus mRNA: synthesis of bacteriophage Q beta proteins in a cell-free extract from wheat embryo.病毒信使核糖核酸的翻译：在小麦胚无细胞提取物中合成噬菌体Qβ蛋白
J Virol. 1973 Dec;12(6):1434-41. doi: 10.1128/JVI.12.6.1434-1441.1973.
5
Efficient translation of tobacco mosaic virus RNA and rabbit globin 9S RNA in a cell-free system from commercial wheat germ.在由市售小麦胚芽制备的无细胞体系中烟草花叶病毒RNA和兔珠蛋白9S RNA的高效翻译。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2330-4. doi: 10.1073/pnas.70.8.2330.
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