Comoglu Tansel, Arisoy Sema, Akkus Zeynep Burcu
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06100, Tandogan-Ankara, Turkey.
Curr Top Med Chem. 2017;17(13):1490-1506. doi: 10.2174/1568026616666161222101355.
Drug delivery to the brain is an engaged research topic in the field of nanomedicine. The passage of therapeutics into the brain parenchyma is more complicated than other body tissues due to it is limited by restrict barrier structure called blood-brain barrier (BBB). Nanotechnology holds great promise to overcome the BBB and thereby enable treatment of neurodegenerative diseases. Nanocarriers have been investigated several times as effective brain drug delivery systems in the past few decades. Physicochemical properties and surface modifications of these carriers play a significant role in terms of brain up-taking of nanocarriers. Chemical structures of possible nano sized drug delivery systems have an importance in terms of interactions between cell membranes of brain endothelial cell lines and these interactions can be modified with surface coating strategies using suitable agents. Particle size, surface charge and total molecular mass are also crucial issues which require special attention in order to better understand appropriate properties of nanocarriers to overcome the BBB structure. Different strategies have been demonstrated to facilitate the passage of nanoparticles into the brain parenchyma including attachment of targeting ligands on the nanoparticles' surfaces; this attempt provides site specific action in the brain tissues. This study aims to provide a review of nanocarriers for effective brain drug delivery, in the light of current literature.
药物递送至脑部是纳米医学领域一个备受关注的研究课题。由于治疗药物进入脑实质受到称为血脑屏障（BBB）的限制屏障结构的制约，其过程比进入身体其他组织更为复杂。纳米技术有望克服血脑屏障，从而实现对神经退行性疾病的治疗。在过去几十年中，纳米载体作为有效的脑药物递送系统已被多次研究。这些载体的物理化学性质和表面修饰在纳米载体的脑摄取方面起着重要作用。潜在的纳米级药物递送系统的化学结构对于脑内皮细胞系细胞膜之间的相互作用具有重要意义，并且可以通过使用合适的试剂进行表面包被策略来改变这些相互作用。粒径、表面电荷和总分子量也是关键问题，为了更好地理解纳米载体克服血脑屏障结构的合适性质，需要特别关注。已经证明了不同的策略来促进纳米颗粒进入脑实质，包括在纳米颗粒表面连接靶向配体；这种尝试在脑组织中提供了位点特异性作用。本研究旨在根据当前文献，对用于有效脑药物递送的纳米载体进行综述。
