Teleanu Daniel Mihai, Chircov Cristina, Grumezescu Alexandru Mihai, Teleanu Raluca Ioana
Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Pharmaceutics. 2019 Feb 26;11(3):101. doi: 10.3390/pharmaceutics11030101.
The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood⁻brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented.
神经纳米医学领域最近已成为神经科学与纳米技术之间的桥梁。这种新视角的可能性对于严重中枢神经系统疾病的诊断和治疗策略而言前景广阔。因此，能够穿透血脑屏障（BBB）并到达脑实质的纳米载体的开发可能会带来突破性疗法，从而提高被诊断患有脑部疾病患者的预期寿命和生活质量。本综述的目的是总结最近开发的可用于将成像和治疗剂递送至大脑的有机、无机和生物纳米载体，以及纳米材料在脑癌、神经退行性疾病和中风方面的最新研究。此外，还简要介绍了与使用这些纳米载体相关的主要挑战和局限性。
