Levitt Joshua, Choo Hyunwoo J, Smith Kelsey A, LeBlanc Brian W, Saab Carl Y
Center for Biomedical Engineering, Brown University, Providence, RI, USA.
Warren Alpert Medical School, Brown University, Providence, RI, USA.
Brain Res Bull. 2017 Apr;130:75-80. doi: 10.1016/j.brainresbull.2016.12.011. Epub 2016 Dec 23.
Recent studies in our laboratory showed that cortical theta oscillations correlate with pain in rodent models. In this study, we sought to validate our pre-clinical data using EEG recordings in humans during immersion of the hand in ice cold water, a moderately noxious stimulus. Power spectral analysis shows that an increase in pain score is associated with an increase in power amplitude within a frequency range of 6-7Hz at the frontal (Fz) electrode. These results are consistent with our previous pre-clinical animal studies and the clinical literature. We also report a novel reduction in power at the caudal (O1) electrode within a broader 3-30Hz rand and decreased coherence between Fz and C3, C4 electrodes within the theta (4-8Hz) and low beta (13-21Hz) bands, while coherence (an indirect measure of functional connectivity) between Fz and O1 increased within the theta and alpha (8-12Hz) bands. We argue that pain is associated with EEG frontal synchrony and caudal asynchrony, leading to the disruption of cortico-cortical connectivity.
我们实验室最近的研究表明，在啮齿动物模型中，皮层θ振荡与疼痛相关。在本研究中，我们试图通过在人类将手浸入冰冷水中（一种中度有害刺激）时进行脑电图记录来验证我们的临床前数据。功率谱分析表明，疼痛评分的增加与额叶（Fz）电极处6 - 7Hz频率范围内的功率振幅增加相关。这些结果与我们之前的临床前动物研究以及临床文献一致。我们还报告了一个新发现，即在更宽的3 - 30Hz范围内，尾叶（O1）电极处的功率降低，并且在θ（4 - 8Hz）和低β（13 - 21Hz）频段内，Fz与C3、C4电极之间的相干性降低，而在θ和α（8 - 12Hz）频段内，Fz与O1之间的相干性（功能连接性的间接测量指标）增加。我们认为，疼痛与脑电图额叶同步和尾叶异步相关，导致皮质 - 皮质连接性中断。
