O'Connor Leigh, Gilmour Jane, Bonifer Constanze
Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, UK.
Yale J Biol Med. 2016 Dec 23;89(4):513-525. eCollection 2016 Dec.
Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm for a ubiquitously expressed transcription factor and is involved in regulating the expression of genes associated with a wide range of cellular processes in mammalian cells. Sp1 can interact with a range of proteins, including other transcription factors, members of the transcription initiation complex and epigenetic regulators, enabling tight regulation of its target genes. In this review, we discuss the mechanisms involved in Sp1-mediated transcriptional regulation, as well as how a ubiquitous transcription factor can be involved in establishing a tissue-specific pattern of gene expression and mechanisms by which its activity may be regulated. We also consider the role of Sp1 in human diseases, such as cancer.
Sp1属于包含26个成员的Sp/KLF转录因子家族。它是普遍表达的转录因子的一个范例，参与调节与哺乳动物细胞中广泛细胞过程相关的基因表达。Sp1可以与一系列蛋白质相互作用，包括其他转录因子、转录起始复合物成员和表观遗传调节因子，从而实现对其靶基因的严格调控。在本综述中，我们讨论了Sp1介导的转录调控所涉及的机制，以及一种普遍存在的转录因子如何参与建立组织特异性基因表达模式及其活性可能被调节的机制。我们还考虑了Sp1在人类疾病如癌症中的作用。
