Khaiboullina Svetlana F, Abdulkhakov Sayar, Khalikova Alsu, Safina Dilyara, Martynova Ekaterina V, Davidyuk Yuriy, Khuzin Felix, Faizullina Rezeda, Lombardi Vincent C, Cherepnev Georgi V, Rizvanov Albert A
Institute of Fundamental Medicine and Biology, Kazan Federal University Kazan, Russia.
Institute of Fundamental Medicine and Biology, Kazan Federal UniversityKazan, Russia; Kazan State Medical UniversityKazan, Russia.
Front Microbiol. 2016 Dec 15;7:1916. doi: 10.3389/fmicb.2016.01916. eCollection 2016.
Gastroduodenitis caused by , often acquired in early childhood, is found in about 50% of the adult population. Although infections can remain asymptomatic, its virulence factors usually trigger epithelial vacuolization and degeneration, loss of microvilli, disintegration of cytoplasm, and leukocyte accumulation. It is believed that leukocyte infiltration is driven by cytokines produced locally in infected tissue. However, so far little is known about changes in serum cytokines in juvenile patients infected with . Serum cytokine profiles were analyzed in 62 juvenile patients diagnosed with gastroduodenitis using the Bio-Plex multiplex assay. infection was confirmed in 32 patients, while 30 patients were -free. Cytokines CXCL5 and CXCL6, potent neutrophil chemoattractants, were upregulated in all patients diagnosed with gastroduodenitis. Serum levels of IL8, a prototype neutrophil attractant, remained unchanged in subjects with gastroduodenitis relative to controls. Therefore, our data suggest that CXCL5 and CXCL6 play a role in directing neutrophil trafficking into inflamed gastroduodenal tissue. In addition, the CCL25/GM-CSF ratio differed significantly between -positive and -negative juveniles. Further, study is needed to evaluate the role of CCL25 and GM-CSF in the pathogenesis of the different etiologies of gastroduodenitis.
由 引起的胃十二指肠炎症通常在儿童早期感染，在约50%的成年人群中被发现。虽然 感染可能无症状，但其毒力因子通常会引发上皮细胞空泡化和变性、微绒毛丧失、细胞质解体以及白细胞积聚。据信白细胞浸润是由感染组织局部产生的细胞因子驱动的。然而，到目前为止，对于感染 的青少年患者血清细胞因子的变化知之甚少。使用Bio-Plex多重检测法对62例诊断为胃十二指肠炎症的青少年患者的血清细胞因子谱进行了分析。32例患者确诊感染 ，而30例患者未感染 。细胞因子CXCL5和CXCL6是有效的中性粒细胞趋化因子，在所有诊断为胃十二指肠炎症的患者中均上调。相对于对照组，胃十二指肠炎症患者中作为中性粒细胞趋化因子原型的IL8血清水平保持不变。因此，我们的数据表明CXCL5和CXCL6在引导中性粒细胞进入发炎的胃十二指肠组织中发挥作用。此外，CCL25/GM-CSF比值在感染 阳性和阴性的青少年之间存在显著差异。此外，需要进一步研究来评估CCL25和GM-CSF在胃十二指肠炎症不同病因发病机制中的作用。 （注：原文中部分“ ”处信息缺失，可能影响完整理解和准确翻译）
