主动-被动路径长度编码（APPLE）多普勒光学相干断层扫描
Active-passive path-length encoded (APPLE) Doppler OCT.
作者信息
Wartak Andreas, Haindl Richard, Trasischker Wolfgang, Baumann Bernhard, Pircher Michael, Hitzenberger Christoph K
机构信息
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20 / 4L, 1090 Vienna, Austria.
出版信息
Biomed Opt Express. 2016 Nov 23;7(12):5233-5251. doi: 10.1364/BOE.7.005233. eCollection 2016 Dec 1.
Abstract
We present a novel active-passive path-length encoded (APPLE) swept source Doppler optical coherence tomography (DOCT) approach, enabling three-dimensional velocity vector reconstruction of moving particles without prior knowledge of the orientation of motion. The developed APPLE DOCT setup allows for non-invasive blood flow measurements and was primarily designed for quantitative human ocular blood flow investigations. The system's performance was demonstrated by flow phantom as well as retinal vessel bifurcation measurements. Furthermore, total retinal blood flow - a biomarker aiding in diagnosis and monitoring of major ocular diseases such as glaucoma, diabetic retinopathy or central/branch retinal vein occlusion - was determined in the eyes of healthy human volunteers.
摘要
我们提出了一种新型的主动-被动光程编码（APPLE）扫频源多普勒光学相干断层扫描（DOCT）方法，无需事先了解运动方向，就能对移动粒子进行三维速度矢量重建。所开发的APPLE DOCT装置可进行非侵入性血流测量，主要用于定量人体眼部血流研究。通过流动模型以及视网膜血管分支测量验证了该系统的性能。此外，还在健康人类志愿者眼中测定了总视网膜血流量，这是一种有助于诊断和监测青光眼、糖尿病视网膜病变或视网膜中央/分支静脉阻塞等主要眼部疾病的生物标志物。
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