Doblhoff-Dier Veronika, Schmetterer Leopold, Vilser Walthard, Garhöfer Gerhard, Gröschl Martin, Leitgeb Rainer A, Werkmeister René M
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
Biomed Opt Express. 2014 Jan 28;5(2):630-42. doi: 10.1364/BOE.5.000630. eCollection 2014 Feb 1.
We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray's law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood's velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at lower diameters. Good agreement with literature data and the large range and high measurement sensitivity point to a high potential for further investigations.
我们展示了一种系统，该系统能够结合具有正交检测平面的双光束傅里叶域多普勒光学相干断层扫描和基于眼底相机的视网膜血管分析仪来测量视网膜总血流量。我们的结果显示静脉和动脉血流具有高度一致性，这证实了测量的有效性。根据默里定律，发现血管直径与血流量之间的对数-对数回归系数约为3。在较大直径（>60 µm）时，血液速度与血管直径呈线性比例关系，但在较小直径时明显偏离线性关系。与文献数据的良好一致性以及较大的测量范围和高测量灵敏度表明该系统具有进一步研究的巨大潜力。
