肉柱对左心室舒张顺应性的影响：切断肉柱后顺应性改善。
The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting.
作者信息
Halaney David L, Sanyal Arnav, Nafissi Navid A, Escobedo Daniel, Goros Martin, Michalek Joel, Acevedo Pedro J, Pérez William, Patricia Escobar G, Feldman Marc D, Han Hai-Chao
机构信息
Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229.
Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249.
出版信息
J Biomech Eng. 2017 Mar 1;139(3):0310121-8. doi: 10.1115/1.4035585.
The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p < 0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.
肉柱在调节左心室（LV）舒张顺应性方面的作用仍不清楚。本研究的目的是确定肉柱对左心室舒张顺应性的贡献。在6例左心室肥厚患者的人体心脏外植体中，于基线时及肉柱切断后测量左心室压力-容积顺应性曲线。还通过有限元模型（FEM）模拟分析了肉柱切断的效果。我们的结果表明，肉柱切断后左心室顺应性得到改善（p < 0.001）。有限元模拟进一步表明，更硬的肉柱会进一步降低左心室顺应性，并且肉柱的存在会降低心尖处的壁应力。总之，我们证明左心室和肉柱的完整性对于维持左心室僵硬度很重要，肉柱的丧失会导致左心室顺应性增加。
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