Wasilewska Krystyna, Pawlak Aleksandra, Kostrzewa Grażyna, Sobczyk-Kopcioł Agnieszka, Kaczorowska Aleksandra, Badowski Jarosław, Brzozowska Małgorzata, Drygas Wojciech, Piwoński Jerzy, Bielecki Wojciech, Płoski Rafał
Department of Medical Genetics, Medical University of Warsaw, ul. Pawińskiego 3c, 02-106 Warsaw, Poland.
Department of Forensic Medicine, Medical University of Warsaw, ul. Oczki 1, 02-007 Warsaw, Poland; Department of Clinical Nursing, Medical University of Warsaw, ul. Erazma Ciołka 27, 01-445 Warsaw, Poland.
Psychoneuroendocrinology. 2017 Mar;77:84-89. doi: 10.1016/j.psyneuen.2016.12.003. Epub 2016 Dec 7.
In the light of contradictory results concerning OXTR polymorphism rs53576 and depression, we decided to verify the potential association between the two on 1) a large, ethnically homogenous sample of 1185 individuals who completed the Beck Depression Inventory (BDI), as well as on 2) a sample of 763 suicide victims. In the population sample, AA males showed significantly lower BDI scores (p=0.005, p=0.030). Exploratory analyses suggested that this effect was limited to a subgroup within 0-9 BDI score range (p=0.0007, U-Mann Whitney test), whereas no main effect on depressive symptoms (BDI>9) was found. In the suicide sample no association with rs53576 genotype was present. Exploratory analyses in suicides revealed higher blood alcohol concentration (BAC) among AA than GG/GA males (p=0.014, U-Mann Whitney test). Our results show that the OXTR rs53576 variant modulates the mood in male individuals and may positively correlate with alcohol intake among male suicides, but is not associated with suicide or depression. The study adds to the growing knowledge on rs53576 genotype characteristics.
鉴于关于OXTR基因多态性rs53576与抑郁症的结果相互矛盾，我们决定在以下两组人群中验证两者之间的潜在关联：1）1185名完成贝克抑郁量表（BDI）的种族同质大样本个体；2）763名自杀受害者样本。在总体样本中，AA基因型男性的BDI得分显著更低（p = 0.005，p = 0.030）。探索性分析表明，这种效应仅限于BDI得分在0 - 9范围内的亚组（p = 0.0007，U - 曼 - 惠特尼检验），而未发现对抑郁症状（BDI>9）有主要影响。在自杀样本中，未发现与rs53576基因型存在关联。对自杀者的探索性分析显示，AA基因型男性的血液酒精浓度（BAC）高于GG/GA基因型男性（p = 0.014，U - 曼 - 惠特尼检验）。我们的结果表明，OXTR rs53576变异体调节男性个体的情绪，可能与男性自杀者的酒精摄入量呈正相关，但与自杀或抑郁症无关。该研究增加了对rs53576基因型特征的认识。
