Park Sora, Eo Wankyu, Lee Sookyung
1 Kyung Hee University, Seoul, Republic of Korea.
Integr Cancer Ther. 2018 Mar;17(1):65-72. doi: 10.1177/1534735416684015. Epub 2016 Dec 26.
This study aimed to identify the relationship between health-related quality of life (HRQoL) measured by the Functional Assessment Cancer Therapy-General (FACT-G) and survival in metastatic colorectal cancer (mCRC) patients.
The clinical characteristics and FACT-G scores were retrospectively reviewed in mCRC patients who visited the Cancer Center of Korean Medicine. The overall survival (OS) was calculated and compared using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analyses were performed based on clinical characteristics and FACT-G scores. To identify significant differences in answer frequency, χ tests and Fisher's exact tests were used.
A total of 58 patients were reviewed. The proportion of patients who had an Eastern Cooperative Oncology Group-Performance Status ≥ 2 was 43.1%, multiple distant metastatic sites was 77.6%, liver metastases was 43.1%, been previously treated was 89.7%, and received more than the second-line chemotherapy was 75.5%. The mean total FACT-G score was 65.3 (median 65.6). The median OS was 7 months. There was no significant difference in OS between the 2 groups divided by the median values of FACT-G total and subscores. In univariate analyses, functional well-being (FWB) score had a significant impact on survival. In multivariate analyses, presence of liver metastasis, FACT-G total score, and FWB score were significant prognostic predictors of survival. No statistically different answer frequency was observed for any question regarding FWB.
This study found that FACT-G total and FWB scores were potential prognostic factors for predicting OS in relapsed or refractory mCRC patients treated with Korean Medicine.
本研究旨在确定通过癌症治疗功能评估通用量表（FACT-G）测量的健康相关生活质量（HRQoL）与转移性结直肠癌（mCRC）患者生存率之间的关系。
对就诊于韩国医学癌症中心的mCRC患者的临床特征和FACT-G评分进行回顾性分析。采用Kaplan-Meier法和对数秩检验计算并比较总生存期（OS）。基于临床特征和FACT-G评分进行单因素和多因素Cox回归分析。为确定回答频率的显著差异，使用χ检验和Fisher精确检验。
共纳入58例患者进行分析。东部肿瘤协作组体能状态≥2的患者比例为43.1%，有多个远处转移部位的患者比例为77.6%，有肝转移的患者比例为43.1%，既往接受过治疗的患者比例为89.7%，接受过二线以上化疗的患者比例为75.5%。FACT-G总评分的平均值为65.3（中位数为65.6）。中位总生存期为7个月。根据FACT-G总分及各子评分的中位数将患者分为两组，两组的总生存期无显著差异。单因素分析中，功能幸福感（FWB）评分对生存有显著影响。多因素分析中，肝转移的存在、FACT-G总分及FWB评分是生存的显著预后预测因素。关于FWB的任何问题，均未观察到有统计学差异的回答频率。
本研究发现，FACT-G总分及FWB评分是预测接受韩医治疗的复发或难治性mCRC患者总生存期的潜在预后因素。
