Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany.
Neuroelectronics, Munich School of Bioengineering, Technical University of Munich (TUM), Germany & BCCN Munich, Boltzmannstr. 11, 85748 Garching, Germany.
Biosensors (Basel). 2016 Dec 23;7(1):1. doi: 10.3390/bios7010001.
Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.
石墨烯是一种很有前途的材料，具有与生物电子学应用相关的特性。本工作通过阻抗谱研究了在柔性聚酰亚胺基底上密集排列的石墨烯微电极（GMEA）的性能。通过测量急性心脏组织和心肌细胞的电活动，测试了 GMEA 的生物相容性和体外记录的适用性。记录显示，心脏组织记录的信号噪声比为 65 ± 15，HL-1 细胞的信号噪声比为 20 ± 10，这表明记录结果具有令人鼓舞的信噪比。考虑到器件的低噪声和优异的鲁棒性，传感器阵列适用于各种具有生物学相关性的应用。
