洛美沙星和替马沙星对引起腹泻病原体的体外活性
In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea.
作者信息
Segreti J, Nelson J A, Goodman L J, Kaplan R L, Trenholme G M
机构信息
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1385-7. doi: 10.1128/AAC.33.8.1385.
Abstract
The in vitro activities of temafloxacin (A63004) and lomefloxacin (SC-47111; NY-198) were compared with those of seven other antibiotics against 146 isolates of bacterial enteric pathogens, including Campylobacter jejuni and Campylobacter coli. Ciprofloxacin was the most active drug against the Salmonella, Shigella, Yersinia, and Vibrio spp. tested. Lomefloxacin, temafloxacin, and difloxacin were the most active drugs tested against Campylobacter spp. (MIC for 90% of strains, 0.125 to 0.25 micrograms/ml).
摘要
将替马沙星（A63004）和洛美沙星（SC-47111；NY-198）的体外活性与其他七种抗生素针对146株肠道病原菌（包括空肠弯曲菌和结肠弯曲菌）的活性进行了比较。环丙沙星是针对所测试的沙门氏菌、志贺氏菌、耶尔森氏菌和弧菌属最具活性的药物。洛美沙星、替马沙星和二氟沙星是针对弯曲菌属测试的最具活性的药物（90%菌株的MIC为0.125至0.25微克/毫升）。
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