体内生物发光成像的前景：在基础和转化神经科学中的应用
Perspectives of In Vivo Bioluminescence Imaging: Application to Basic and Translational Neuroscience.
作者信息
Vogel Stefanie, Collmann Franziska M, Hoehn Mathias
机构信息
In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Cologne. Germany.
In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Gleuelerstrasse 50, D-50931 Cologne. Germany.
出版信息
Curr Pharm Des. 2017;23(13):1963-1973. doi: 10.2174/1381612822666161226151811.
BACKGROUND
In vivo bioluminescence imaging has been used extensively for screening assays and for qualitative determination of localization of cells, in particular in cancer studies.
OBJECTIVE
In this review we show the potential of this noninvasive molecular imaging modality to investigate gene activity, dynamic processes, and translational disease processes, all under true in vivo conditions with the specific focus on brain.
RESULTS
We demonstrate a range of applications of bioluminescence imaging in basic and translational neuroscience. Here, emphasis is on the contribution of bioluminescence imaging of the brain to the elucidation of cellular and genetic mechanisms, understanding of dynamic processes, and to the discussion of disease characterization and therapeutic strategies.
背景
体内生物发光成像已广泛应用于筛选试验以及细胞定位的定性测定，尤其是在癌症研究中。
目的
在本综述中，我们展示了这种非侵入性分子成像方式在研究基因活性、动态过程和转化疾病过程方面的潜力，所有这些均在真正的体内条件下进行，特别关注大脑。
结果
我们展示了生物发光成像在基础和转化神经科学中的一系列应用。在此，重点是大脑生物发光成像对阐明细胞和遗传机制、理解动态过程以及对疾病特征和治疗策略讨论的贡献。
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