新的修饰型单端孢霉烯族毒素由拟分枝孢镰刀菌突变菌株在固体培养中积累产生。
New modified trichothecenes accumulated in solid culture by mutant strains of Fusarium sporotrichioides.
作者信息
McCormick S P, Taylor S L, Plattner R D, Beremand M N
机构信息
Northern Regional Research Center, U.S. Department of Agriculture, Peoria, Illinois 61604.
出版信息
Appl Environ Microbiol. 1989 Sep;55(9):2195-9. doi: 10.1128/aem.55.9.2195-2199.1989.
Abstract
Mutant strains of Fusarium sporotrichioides NRRL 3299 deficient in the ability to synthesize T-2 toxin were examined on solid rice medium. Five novel alicyclic trichothecenes were isolated: 11 alpha-hydroxytrichodiene; tricho-9-ene-2 alpha,3 alpha,11 alpha-triol; tricho-9-ene-2 alpha,3 alpha,8 alpha,11 alpha-tetraol; tricho-9-ene-2 alpha,3 alpha,8 beta,11 alpha-tetraol; and tricho-9-ene-2 alpha,3 alpha,11 alpha,16-tetraol.
摘要
在固体大米培养基上检测了禾谷镰刀菌NRRL 3299中缺乏合成T-2毒素能力的突变菌株。分离出了五种新的脂环族单端孢霉烯族毒素：11α-羟基单端孢霉烯；单端孢-9-烯-2α,3α,11α-三醇；单端孢-9-烯-2α,3α,8α,11α-四醇；单端孢-9-烯-2α,3α,8β,11α-四醇；以及单端孢-9-烯-2α,3α,11α,16-四醇。
相似文献
1
New modified trichothecenes accumulated in solid culture by mutant strains of Fusarium sporotrichioides.新的修饰型单端孢霉烯族毒素由拟分枝孢镰刀菌突变菌株在固体培养中积累产生。
Appl Environ Microbiol. 1989 Sep;55(9):2195-9. doi: 10.1128/aem.55.9.2195-2199.1989.
2
Trichothecenes accumulated in liquid culture of a mutant of Fusarium sporotrichioides NRRL 3299.单端孢霉烯族毒素在拟分枝孢镰刀菌NRRL 3299突变体的液体培养物中积累。
Appl Environ Microbiol. 1989 Sep;55(9):2190-4. doi: 10.1128/aem.55.9.2190-2194.1989.
3
Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3299.拟枝孢镰刀菌NRRL 3299突变菌株对可能的T-2毒素前体的生物转化
Appl Environ Microbiol. 1990 Mar;56(3):702-6. doi: 10.1128/aem.56.3.702-706.1990.
4
Isolation and characterization of two new trichothecenes from Fusarium sporotrichioides strain M-1-1.从串珠镰刀菌菌株M-1-1中分离并鉴定两种新的单端孢霉烯族毒素。
Appl Environ Microbiol. 1981 Sep;42(3):541-3. doi: 10.1128/aem.42.3.541-543.1981.
5
Leucine auxotrophy specifically alters the pattern of trichothecene production in a T-2 toxin-producing strain of Fusarium sporotrichioides.亮氨酸营养缺陷型特异性改变了产T-2毒素的拟分枝孢镰刀菌菌株中单端孢霉烯族毒素的产生模式。
Appl Environ Microbiol. 1988 Nov;54(11):2759-66. doi: 10.1128/aem.54.11.2759-2766.1988.
6
Ancymidol blocks trichothecene biosynthesis and leads to accumulation of trichodiene in Fusarium sporotrichioides and Gibberella pulicaris.Ancymidol可阻断单端孢霉烯生物合成，并导致拟分枝孢镰刀菌和赤霉病菌中trichodiene的积累。
Appl Environ Microbiol. 1987 Aug;53(8):1860-5. doi: 10.1128/aem.53.8.1860-1865.1987.
7
Comparative yields of T-2 toxin and related trichothecenes from five toxicologically important strains of Fusarium sporotrichioides.来自五株毒理学重要的拟枝孢镰刀菌菌株的T-2毒素及相关单端孢霉烯族毒素的比较产量。
Appl Environ Microbiol. 1987 Apr;53(4):693-6. doi: 10.1128/aem.53.4.693-696.1987.
8
Biosynthesis of Fusarium culmorum trichothecenes. The roles of isotrichodermin and 12,13-epoxytrichothec-9-ene.禾谷镰刀菌单端孢霉烯族毒素的生物合成。异单端孢霉烯和12,13-环氧单端孢霉-9-烯的作用。
J Biol Chem. 1990 Apr 25;265(12):6713-25.
9
Structures of deepoxytrichothecene metabolites from 3'-hydroxy HT-2 toxin and T-2 tetraol in rats.大鼠体内3'-羟基HT-2毒素和T-2四醇的深氧单端孢霉烯族毒素代谢产物的结构
Appl Environ Microbiol. 1985 Sep;50(3):676-9. doi: 10.1128/aem.50.3.676-679.1985.
10
Mycotoxin production by Fusarium oxysporum and Fusarium sporotrichioides isolated from Baccharis spp. from Brazil.从巴西的巴卡里斯属植物中分离出的尖孢镰刀菌和拟分枝孢镰刀菌产生霉菌毒素的情况。
Appl Environ Microbiol. 1989 Jan;55(1):254-5. doi: 10.1128/aem.55.1.254-255.1989.
引用本文的文献
1
Attempting to Create a Pathway to 15-Deacetylcalonectrin with Limited Accumulation in Cultures of Mutants: Insight into Trichothecene Biosynthesis Machinery.试图利用突变体培养物中有限积累的 15-去乙酰 calonectrin 来创建一条途径：对三萜烯生物合成机制的深入了解。
Int J Mol Sci. 2024 Jun 11;25(12):6414. doi: 10.3390/ijms25126414.
2
A Role in 15-Deacetylcalonectrin Acetylation in the Non-Enzymatic Cyclization of an Earlier Bicyclic Intermediate in Trichothecene Biosynthesis.15-去乙酰卡龙菌素乙酰化在单端孢霉烯生物合成中早期双环中间体非酶环化过程中的作用。
Int J Mol Sci. 2024 Apr 12;25(8):4288. doi: 10.3390/ijms25084288.
3
Analysis of substrate specificity of cytochrome P450 monooxygenases involved in trichothecene toxin biosynthesis.分析参与单端孢霉烯族毒素生物合成的细胞色素 P450 单加氧酶的底物特异性。
Appl Microbiol Biotechnol. 2024 Dec;108(1):152. doi: 10.1007/s00253-023-12950-1. Epub 2024 Jan 6.
4
Identification of polyketide synthase genes required for aspinolide biosynthesis in Trichoderma arundinaceum.鉴定在绿色木霉中合成aspernolide 所需的聚酮合酶基因。
Appl Microbiol Biotechnol. 2022 Nov;106(21):7153-7171. doi: 10.1007/s00253-022-12182-9. Epub 2022 Sep 27.
5
Involvement of Trichoderma trichothecenes in the biocontrol activity and induction of plant defense-related genes.木霉三萜烯在生物防治活性和诱导植物防御相关基因中的作用。
Appl Environ Microbiol. 2012 Jul;78(14):4856-68. doi: 10.1128/AEM.00385-12. Epub 2012 May 4.
6
Accumulation of Trichothecenes in Liquid Cultures of a Fusarium sporotrichioides Mutant Lacking a Functional Trichothecene C-15 Hydroxylase.镰刀菌突变体在缺乏功能性的交链孢菌烯醇 C-15 羟化酶的液体培养物中积累交链孢酚。
Appl Environ Microbiol. 1997 May;63(5):1685-8. doi: 10.1128/aem.63.5.1685-1688.1997.
7
Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance.镰刀菌属中单端孢霉烯族毒素的生物合成：化学、遗传学及意义
Microbiol Rev. 1993 Sep;57(3):595-604. doi: 10.1128/mr.57.3.595-604.1993.
8
Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3299.拟枝孢镰刀菌NRRL 3299突变菌株对可能的T-2毒素前体的生物转化
Appl Environ Microbiol. 1990 Mar;56(3):702-6. doi: 10.1128/aem.56.3.702-706.1990.
本文引用的文献
1
Trichothecene Biosynthesis in Fusarium sporotrichioides: Origin of the Oxygen Atoms of T-2 Toxin.木霉梭孢镰孢菌中 trichothecene 的生物合成：T-2 毒素氧原子的起源。
Appl Environ Microbiol. 1986 Mar;51(3):493-7. doi: 10.1128/aem.51.3.493-497.1986.
2
Production of Nivalenol and Fusarenone-X by Fusarium tricinctum Fn-2B on a Rice Substrate.三圈镰孢菌 Fn-2B 在水稻基质上产生雪腐镰刀菌烯醇和呋塞米烯-X。
Appl Environ Microbiol. 1984 Oct;48(4):857-8. doi: 10.1128/aem.48.4.857-858.1984.
3
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.鉴定averantin为黄曲霉毒素B1前体：确定其在生物合成途径中的位置。
Appl Environ Microbiol. 1980 Apr;39(4):835-9. doi: 10.1128/aem.39.4.835-839.1980.
4
T-2 toxin production by Fusarium tricinctum on solid substrate.三线镰刀菌在固体基质上产生T-2毒素。
Appl Microbiol. 1971 Apr;21(4):739-42. doi: 10.1128/am.21.4.739-742.1971.
5
Structure-function relationship in the 12,13-epoxytrichothecenes. Novel inhibitors of protein synthesis.12,13-环氧单端孢霉烯族毒素的结构-功能关系。新型蛋白质合成抑制剂。
Biochem Biophys Res Commun. 1974 Apr 8;57(3):838-44. doi: 10.1016/0006-291x(74)90622-6.
6
Detection and analysis of epoxides with 4-(p-Nitrobenzyl)-pyridine.用4-（对硝基苄基）吡啶检测和分析环氧化物
Bull Environ Contam Toxicol. 1974 Dec;12(6):759-64. doi: 10.1007/BF01685927.
7
7 alpha-hydroxytrichodermol, a new trichothecene from Myrothecium roridum.7α-羟基拟枝孢镰刀菌素，一种来自串珠霉的新型单端孢霉烯族毒素。
Appl Environ Microbiol. 1985 Nov;50(5):1225-8. doi: 10.1128/aem.50.5.1225-1228.1985.
8
Secondary metabolites from Fusarium. Two new modified trichothecenes from Fusarium sporotrichioides MC-72083.镰刀菌产生的次生代谢产物。来自拟分枝孢镰刀菌MC - 72083的两种新的修饰单端孢霉烯族毒素。
J Nat Prod. 1987 Sep-Oct;50(5):897-902. doi: 10.1021/np50053a021.
9
Isolation and characterization of mutants blocked in T-2 toxin biosynthesis.T-2毒素生物合成受阻突变体的分离与鉴定
Appl Environ Microbiol. 1987 Aug;53(8):1855-9. doi: 10.1128/aem.53.8.1855-1859.1987.
10
Non-macrocyclic trichothecenes.
Nat Prod Rep. 1988 Apr;5(2):187-209. doi: 10.1039/np9880500187.
Zotero 插件