用于卓越单分子检测的光增敏等离子纳米孔生物传感器。
Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection.
机构信息
Department of Biomedical Engineering, The Technion -Israel Institute of Technology, Haifa, 32000, Israel.
Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
出版信息
Adv Mater. 2017 Mar;29(9). doi: 10.1002/adma.201605442. Epub 2016 Dec 27.
A stacked plasmonic nanowell-nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal-to-background (S/B) ratio for single-molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single-DNA sensing.
堆叠的等离子体纳米井-纳米孔生物传感器强烈抑制了体相的背景荧光，并使荧光强度净增强十倍以上。该器件在超低激发激光强度下进行单分子检测时提供了极高的信号背景比（S/B），同时保持了极高的单 DNA 传感时间带宽。
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