Norris P G, Hawk J L
Photobiology Unit, St Thomas' Hospital, London, England.
Arch Dermatol. 1989 Oct;125(10):1377-9.
Two patients with severe, disabling polymorphous light eruption, who were unable to tolerate photochemotherapy and who were unresponsive to alternative recognized therapies, are described. In both cases short-term treatment with azathioprine achieved a marked clinical improvement, confirmed by testing with an irradiation monochromator. This response suggests an immunological basis for polymorphous light eruption. Patients with polymorphous light eruption vary considerably with regard to degree of photosensitivity, and while azathioprine therapy should not be considered in the majority of sufferers, we have shown that it can be very helpful in rare patients with exceptionally severe disease.
描述了两名患有严重、致残性多形性日光疹的患者，他们无法耐受光化学疗法，对其他公认的治疗方法也无反应。在这两个病例中，硫唑嘌呤的短期治疗都取得了显著的临床改善，这通过用辐照单色仪进行测试得到了证实。这种反应表明多形性日光疹存在免疫学基础。多形性日光疹患者的光敏程度差异很大，虽然大多数患者不应考虑使用硫唑嘌呤治疗，但我们已经表明，它对极少数患有极其严重疾病的患者可能非常有帮助。
