Grzelczyk Weronika Lucas, Szemraj Janusz, Józefowicz-Korczyńska Magdalena
I Katedra Otolaryngologii Uniwersytetu Medycznego w Łodzi.
Zakładu Biochemii Medycznej Uniwersytetu Medycznego w Łodzi.
Postepy Hig Med Dosw (Online). 2016 Dec 8;70(0):1190-1197.
One of the most common carcinoma occurring in the head and neck is laryngeal cancer. Despite the rapid scientific advances in medicine the prognosis for patients with such type of disease is not satisfying. In the last few years matrix metalloproteinases ‑ MMPs and their tissue inhibitors - TIMPs, mostly MMP‑2 and MMP‑9, arouses a great interest, especially in the process of carcinogenesis. It seems that their impact in the formation and development of laryngeal cancer is significant. MMPs a group of zinc‑ and calcium‑ dependent endopeptidases play crucial role extracellular matrix collagen degradation. That are enzymes, that degrade and the basement membrane by facilitating tumor growth, cell migration and tumor invasion. They are implicated in metastasis and angiogenesis potentiate within the tumor. Clear tendency was observed towards the higher MMPs and TIMPs expression in larynx cancer than in the stroma. Recent studies show correlations between increased MMP‑2 gene expression in the tumor tissue and clinical status, histopathological grading and metastases occurrence. The similar MMP2 over expression dependence were found on tumor recurrence and survival. Many authors pointed out, significant higher MMP‑2 expression as a potential marker of tumor invasiveness and worse prognosis in patients with larynx cancer. However, association of MMP 9 gene expression with laryngeal cancer clinicopathological features and survival of patients are ambiguous. Although, numerous researches show that this relationship does exists. Similar correlations could be found in TIMPs, but further studies are necessary because of small amount of literature.
头颈部最常见的癌之一是喉癌。尽管医学上科学进步迅速，但这类疾病患者的预后并不理想。在过去几年中，基质金属蛋白酶（MMPs）及其组织抑制剂（TIMPs），主要是MMP-2和MMP-9，引起了极大关注，尤其是在致癌过程中。它们在喉癌的形成和发展中的作用似乎很显著。MMPs是一组依赖锌和钙的内肽酶，在细胞外基质胶原蛋白降解中起关键作用。这些酶通过促进肿瘤生长、细胞迁移和肿瘤侵袭来降解基底膜。它们与肿瘤内的转移和血管生成增强有关。在喉癌中观察到MMPs和TIMPs的表达明显高于基质。最近的研究表明，肿瘤组织中MMP-2基因表达增加与临床状态、组织病理学分级和转移发生之间存在相关性。在肿瘤复发和生存方面也发现了类似的MMP2过表达依赖性。许多作者指出，MMP-2表达显著升高是喉癌患者肿瘤侵袭性和预后较差的潜在标志物。然而，MMP 9基因表达与喉癌临床病理特征和患者生存之间的关联尚不明确。尽管众多研究表明这种关系确实存在。在TIMPs中也能发现类似的相关性，但由于文献数量较少，还需要进一步研究。
