Bhukel Anuradha, Madeo Frank, Sigrist Stephan J
a Institute for Biology, Freie Universität Berlin , Berlin , Germany.
b Karl-Franzens Universität Graz , Graz , Austria.
Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. Epub 2016 Dec 27.
All animals form memories to adapt their behavior in a context-dependent manner. With increasing age, however, forming new memories becomes less efficient. While synaptic plasticity promotes memory formation, the etiology of age-induced memory formation remained enigmatic. Previous work showed that simple feeding of polyamine spermidine protects from age-induced memory impairment in Drosophila. Most recent work now shows that spermidine operates directly at synapses, allowing for an autophagy-dependent homeostatic regulation of presynaptic specializations. How exactly autophagic regulations intersect with synaptic plasticity should be an interesting subject for future research.
所有动物都会形成记忆，以便在特定情境下适应性地调整其行为。然而，随着年龄的增长，形成新记忆的效率会降低。虽然突触可塑性促进记忆形成，但年龄诱导的记忆形成的病因仍然不明。先前的研究表明，简单喂食多胺亚精胺可保护果蝇免受年龄诱导的记忆损伤。最新研究表明，亚精胺直接作用于突触，实现对突触前特化的自噬依赖性稳态调节。自噬调节与突触可塑性究竟如何相互作用，应是未来研究的一个有趣课题。
