Joshi Avatar, Kostiuk Benjamin, Rogers Andrew, Teschler Jennifer, Pukatzki Stefan, Yildiz Fitnat H
Department of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA.
Department of Medical Microbiology and Immunology, University of Alberta, Alberta, Canada.
Trends Microbiol. 2017 Apr;25(4):267-279. doi: 10.1016/j.tim.2016.12.003. Epub 2016 Dec 24.
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins. Vibrio cholerae is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes V. cholerae's survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer. This review details the recent insights regarding the structure and function of the T6SS as well as the diverse signals and regulatory pathways that control its activation in V. cholerae.
微生物物种通常存在于复杂的群落中，在那里它们必须避免被捕食，并争夺有利的生态位。VI型分泌系统（T6SS）是一种依赖接触的细菌武器，它可以通过蛋白质毒素的转运直接杀死竞争对手。霍乱弧菌是一种革兰氏阴性病原体，在与邻近的原核和真核竞争对手的拮抗相互作用中可以使用其T6SS。T6SS不仅促进霍乱弧菌在水生和宿主生命周期中的存活，还通过促进水平基因转移影响其进化。这篇综述详细介绍了关于T6SS结构和功能的最新见解，以及控制其在霍乱弧菌中激活的各种信号和调控途径。
