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本文引用的文献

1
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study.耐哌喹恶性疟原虫疟疾的替代标志物:一项表型-基因型关联研究。
Lancet Infect Dis. 2017 Feb;17(2):174-183. doi: 10.1016/S1473-3099(16)30415-7. Epub 2016 Nov 3.
2
Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study.柬埔寨恶性疟原虫疟疾中与双氢青蒿素-哌喹治疗失败相关的遗传标记:一项基因型-表型关联研究。
Lancet Infect Dis. 2017 Feb;17(2):164-173. doi: 10.1016/S1473-3099(16)30409-1. Epub 2016 Nov 3.
3
Artemisinin Action and Resistance in Plasmodium falciparum.青蒿素在恶性疟原虫中的作用与耐药性
Trends Parasitol. 2016 Sep;32(9):682-696. doi: 10.1016/j.pt.2016.05.010. Epub 2016 Jun 9.
4
Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase.mTOR激酶耐药性突变非守门人热点的鉴定
Cell Rep. 2015 Apr 21;11(3):446-59. doi: 10.1016/j.celrep.2015.03.040. Epub 2015 Apr 9.
5
The effects of chromatin organization on variation in mutation rates in the genome.染色质组织对基因组突变率变异的影响。
Nat Rev Genet. 2015 Apr;16(4):213-23. doi: 10.1038/nrg3890. Epub 2015 Mar 3.
6
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.青蒿素类抗疟药作用机制的思考:第1部分——“碳自由基”和“血红素”假说
Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708.
7
Artemisinin resistance in Plasmodium falciparum malaria.恶性疟原虫疟疾中的青蒿素耐药性。
N Engl J Med. 2009 Jul 30;361(5):455-67. doi: 10.1056/NEJMoa0808859.

如何应对抗疟药物耐药性?

How to tackle antimalarial resistance?

机构信息

Medicines for Malaria Venture, Geneva, Switzerland.

出版信息

EMBO Mol Med. 2017 Feb;9(2):133-134. doi: 10.15252/emmm.201607295.

DOI:10.15252/emmm.201607295
PMID:28028013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5286390/
Abstract

In the context of drug resistance, malaria is no exception. Even the latest artemisinins have started to lose their full efficacy in patients. Didier Leroy tells us about the strategies adopted by Medicines for Malaria Venture to reduce this terrible culprit. [Image: see text]

摘要

在耐药性方面,疟疾也不例外。即使是最新的青蒿素类药物,也开始在患者身上失去全部疗效。Didier Leroy 向我们介绍了疟疾药物开发联盟采取的策略,以减少这一可怕的罪魁祸首。[图片:见正文]