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How to tackle antimalarial resistance?
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Drug-resistant malaria advances in Mekong.
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Evidence of Artemisinin-Resistant Plasmodium falciparum Malaria in Eastern India.
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Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study.
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Spread of a single multidrug resistant malaria parasite lineage (PfPailin) to Vietnam.
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Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa.
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Back on TRAC: New trial launched in bid to outpace multidrug-resistant malaria.
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High Antimalarial Efficacy of Dihydroartemisinin-Piperaquine on the China-Myanmar Border: The Calm Before the Storm.
Am J Trop Med Hyg. 2015 Sep;93(3):436-437. doi: 10.4269/ajtmh.15-0349. Epub 2015 Aug 17.
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A brief history of artemisinin: Modes of action and mechanisms of resistance.
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Skirmishing over the scope of the threat.
Science. 2016 Apr 22;352(6284):403. doi: 10.1126/science.352.6284.403. Epub 2016 Apr 21.

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Grasp of dihydroartemisinin resistance in Indonesia: Focused on genetic polymorphisms and new antimalarial.
Narra J. 2023 Dec;3(3):e336. doi: 10.52225/narra.v3i3.336. Epub 2023 Dec 11.
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Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Microbiol Spectr. 2023 Jun 15;11(3):e0523622. doi: 10.1128/spectrum.05236-22. Epub 2023 May 9.
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Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.
Cell Chem Biol. 2023 May 18;30(5):457-469.e11. doi: 10.1016/j.chembiol.2023.04.006. Epub 2023 May 5.
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Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials.
Trends Parasitol. 2021 Aug;37(8):709-721. doi: 10.1016/j.pt.2021.04.006. Epub 2021 May 14.
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MalDA, Accelerating Malaria Drug Discovery.
Trends Parasitol. 2021 Jun;37(6):493-507. doi: 10.1016/j.pt.2021.01.009. Epub 2021 Feb 26.
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K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness .
mBio. 2017 Apr 11;8(2):e00172-17. doi: 10.1128/mBio.00172-17.

本文引用的文献

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A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study.
Lancet Infect Dis. 2017 Feb;17(2):174-183. doi: 10.1016/S1473-3099(16)30415-7. Epub 2016 Nov 3.
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Artemisinin Action and Resistance in Plasmodium falciparum.
Trends Parasitol. 2016 Sep;32(9):682-696. doi: 10.1016/j.pt.2016.05.010. Epub 2016 Jun 9.
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Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase.
Cell Rep. 2015 Apr 21;11(3):446-59. doi: 10.1016/j.celrep.2015.03.040. Epub 2015 Apr 9.
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The effects of chromatin organization on variation in mutation rates in the genome.
Nat Rev Genet. 2015 Apr;16(4):213-23. doi: 10.1038/nrg3890. Epub 2015 Mar 3.
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Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.
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Artemisinin resistance in Plasmodium falciparum malaria.
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