Sherpa Mingma, Lamichaney Rachna, Roy Asitava Deb
Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.
J Cytol. 2016 Oct-Dec;33(4):232-235. doi: 10.4103/0970-9371.190453.
Kimura's disease is a rare, chronic inflammatory disorder of unknown cause. It is endemic in Asia, affecting more number of males than females, with a ratio of 3:1. The typical clinical manifestations include a triad of painless unilateral cervical lymphadenopathy or subcutaneous masses predominantly in the head and neck region, blood and tissue eosinophilia, and an elevated serum immunoglobulin E (IgE) levels. Variable conditions both benign and malignant may mimic Kimura's disease both clinically and on fine needle aspirates. The confirmatory diagnosis is established only by histopathological examination. We report a case of Kimura's disease in a patient who underwent multiple investigations in view of her past history and family history of pulmonary Koch's. Fine needle aspiration cytology (FNAC) was performed thrice with consistently similar result of reactive lymphadenitis with numerous histiocytes and eosinophilia. The final diagnosis of Kimura's disease could finally be established only on histopathological examination.
木村病是一种病因不明的罕见慢性炎症性疾病。该病在亚洲为地方性疾病，男性患者多于女性，比例为3:1。典型的临床表现包括三联征：无痛性单侧颈部淋巴结病或主要位于头颈部区域的皮下肿块、血液和组织嗜酸性粒细胞增多以及血清免疫球蛋白E（IgE）水平升高。各种良性和恶性疾病在临床和细针穿刺抽吸时都可能酷似木村病。只有通过组织病理学检查才能确诊。我们报告一例木村病患者，鉴于其既往史和家族性肺结核病史，该患者接受了多项检查。细针穿刺细胞学检查（FNAC）进行了三次，结果始终类似，为反应性淋巴结炎，伴有大量组织细胞和嗜酸性粒细胞增多。木村病的最终诊断最终只能通过组织病理学检查来确立。
