• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠结肠分泌与结肠运动的相关性：胃饥饿素的作用。

Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.

作者信息

Huang Hsien-Hao, Ting Ching-Heng, Syu Yu-Fong, Chang Shi-Chuan, Chen Chih-Yen

机构信息

Hsien-Hao Huang, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan.

出版信息

World J Gastroenterol. 2016 Dec 14;22(46):10140-10147. doi: 10.3748/wjg.v22.i46.10140.

DOI:10.3748/wjg.v22.i46.10140
PMID:28028362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5155173/
Abstract

AIM

To explore the relationship between colonic secretory function and colonic motility.

METHODS

Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume.

RESULTS

Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 nmol/5 μL enhanced the total fecal weight, accelerated the colonic transit time, and increased the fecal pellet output during the first hour post-injection, while ICV des-acyl ghrelin at 1 nmol/5 μL only accelerated the colonic transit time. These stimulatory effects on colonic motility and/or secretion from acyl ghrelin and des-acyl ghrelin disappeared when the ICV injection volume increased to 10 μL compared with saline controls (10 μL/rat). Additionally, the ICV injection of 10 μL of saline significantly shortened the colonic transit time compared with the ICV injection of 5 μL of saline. The total fecal weight during the first hour post-injection correlated with the colonic transit time and fecal pellet output after the ICV injection of acyl ghrelin (1 nmol/5 μL), whereas the total fecal weight during the first hour post-injection correlated with the fecal pellet output but not the colonic transit time after the ICV injection of des-acyl ghrelin (1 nmol/5 μL).

CONCLUSION

Colonic secretion does not always correlate with colonic motility in response to different colonic stimulations. Acyl ghrelin stimulates colonic secretion.

摘要

目的

探讨结肠分泌功能与结肠动力之间的关系。

方法

使用长期植入脑室内（ICV）和盲肠导管的大鼠模型，我们验证了结肠分泌与结肠运动功能之间的相关性，以及ICV注射体积的作用。

结果

与生理盐水对照组（5μL/只大鼠）相比，1nmol/5μL的ICV酰基胃饥饿素增加了粪便总重量，加快了结肠转运时间，并在注射后第一小时增加了粪便颗粒排出量，而1nmol/5μL的ICV去酰基胃饥饿素仅加快了结肠转运时间。当ICV注射体积增加到10μL时，与生理盐水对照组（10μL/只大鼠）相比，酰基胃饥饿素和去酰基胃饥饿素对结肠动力和/或分泌的这些刺激作用消失。此外，与ICV注射5μL生理盐水相比，ICV注射10μL生理盐水显著缩短了结肠转运时间。ICV注射酰基胃饥饿素（1nmol/5μL）后，注射后第一小时的粪便总重量与结肠转运时间和粪便颗粒排出量相关，而ICV注射去酰基胃饥饿素（1nmol/5μL）后，注射后第一小时的粪便总重量与粪便颗粒排出量相关，但与结肠转运时间无关。

结论

在不同的结肠刺激下，结肠分泌并不总是与结肠动力相关。酰基胃饥饿素刺激结肠分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/4ea96135c6c3/WJG-22-10140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/8d27351db144/WJG-22-10140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/3486d8b93927/WJG-22-10140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/4ea96135c6c3/WJG-22-10140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/8d27351db144/WJG-22-10140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/3486d8b93927/WJG-22-10140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/543b/5155173/4ea96135c6c3/WJG-22-10140-g003.jpg

相似文献

1
Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.大鼠结肠分泌与结肠运动的相关性：胃饥饿素的作用。
World J Gastroenterol. 2016 Dec 14;22(46):10140-10147. doi: 10.3748/wjg.v22.i46.10140.
2
A novel simultaneous measurement method to assess the influence of intracerebroventricular obestatin on colonic motility and secretion in conscious rats.一种评估脑室内肥胖素对清醒大鼠结肠运动和分泌影响的新的同步测量方法。
Peptides. 2010 Jun;31(6):1113-7. doi: 10.1016/j.peptides.2010.03.024. Epub 2010 Mar 23.
3
α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion.α-黑素细胞刺激素调节中枢酰基胃饥饿素诱导的进食、胃肠动力及结肠分泌刺激。
Drug Des Devel Ther. 2017 Aug 16;11:2377-2386. doi: 10.2147/DDDT.S143749. eCollection 2017.
4
Impacts of peripheral obestatin on colonic motility and secretion in conscious fed rats.外周肥胖抑制素对清醒进食大鼠结肠运动和分泌的影响。
Peptides. 2008 Sep;29(9):1603-8. doi: 10.1016/j.peptides.2008.05.003. Epub 2008 May 14.
5
Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats.中枢神经肽Y受体参与第三脑室胃饥饿素诱导的清醒进食大鼠结肠转运时间的改变。
BMC Gastroenterol. 2005 Feb 18;5:5. doi: 10.1186/1471-230X-5-5.
6
Glucagon like peptide-1 accelerates colonic transit via central CRF and peripheral vagal pathways in conscious rats.胰高血糖素样肽-1通过中枢促肾上腺皮质激素释放因子和外周迷走神经途径加速清醒大鼠的结肠转运。
Auton Neurosci. 2007 Jan 30;131(1-2):50-6. doi: 10.1016/j.autneu.2006.06.007. Epub 2006 Aug 28.
7
Intracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats.脑池内去酰基胃饥饿素抑制清醒大鼠的食物摄入和非营养性胃排空。
Int J Mol Med. 2005 Oct;16(4):695-9.
8
Peripheral injection of pancreatic polypeptide enhances colonic transit without eliciting anxiety or altering colonic secretion in rats.外周注射胰多肽可促进大鼠结肠转运，而不会引发焦虑或改变结肠分泌。
Neuropeptides. 2016 Feb;55:67-71. doi: 10.1016/j.npep.2015.10.002. Epub 2015 Oct 22.
9
Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.在大鼠中，粪便颗粒排出量并不总是与因束缚应激和促肾上腺皮质激素释放因子引起的结肠转运相关。
J Gastroenterol. 2007 Apr;42(4):279-82. doi: 10.1007/s00535-006-1947-2. Epub 2007 Apr 26.
10
Enhanced gastrointestinal motility with orally active ghrelin receptor agonists.口服活性胃饥饿素受体激动剂增强胃肠动力。
J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. doi: 10.1124/jpet.108.150193. Epub 2009 Feb 27.

引用本文的文献

1
High-Fat Diet Induced Gut Microbiota Alterations Associating With Ghrelin/Jak2/Stat3 Up-Regulation to Promote Benign Prostatic Hyperplasia Development.高脂饮食诱导肠道微生物群改变，与胃饥饿素/Jak2/Stat3上调相关，促进良性前列腺增生发展。
Front Cell Dev Biol. 2021 Jun 24;9:615928. doi: 10.3389/fcell.2021.615928. eCollection 2021.
2
Good to Know: Baseline Data on Feed Intake, Fecal Pellet Output and Intestinal Transit Time in Guinea Pig as a Frequently Used Model in Gastrointestinal Research.须知：豚鼠作为胃肠道研究中常用模型的采食量、粪便颗粒产量和肠道转运时间的基线数据。
Animals (Basel). 2021 May 28;11(6):1593. doi: 10.3390/ani11061593.
3

本文引用的文献

1
Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats.脑室内注射尿皮质素3通过大鼠体内的促肾上腺皮质激素释放因子受体2抵消中枢酰基胃饥饿素诱导的摄食亢进和胃促动力作用。
Drug Des Devel Ther. 2016 Oct 3;10:3281-3290. doi: 10.2147/DDDT.S113195. eCollection 2016.
2
Peripheral injection of pancreatic polypeptide enhances colonic transit without eliciting anxiety or altering colonic secretion in rats.外周注射胰多肽可促进大鼠结肠转运，而不会引发焦虑或改变结肠分泌。
Neuropeptides. 2016 Feb;55:67-71. doi: 10.1016/j.npep.2015.10.002. Epub 2015 Oct 22.
3
GASTROINTESTINAL MOTILITY DISORDERS IN OBESITY.
肥胖症中的胃肠动力障碍
Acta Endocrinol (Buchar). 2019 Oct-Dec;15(4):497-504. doi: 10.4183/aeb.2019.497.
4
Network-Based Selection of Candidate Markers and Assays to Assess the Impact of Oral Immune Interventions on Gut Functions.基于网络的候选标志物和检测方法选择，以评估口服免疫干预对肠道功能的影响。
Front Immunol. 2019 Nov 13;10:2672. doi: 10.3389/fimmu.2019.02672. eCollection 2019.
5
Ghrelin Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Damage.Ghrelin 可保护人晶状体上皮细胞免受氧化应激损伤。
Oxid Med Cell Longev. 2017;2017:1910450. doi: 10.1155/2017/1910450. Epub 2017 Oct 10.
6
α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion.α-黑素细胞刺激素调节中枢酰基胃饥饿素诱导的进食、胃肠动力及结肠分泌刺激。
Drug Des Devel Ther. 2017 Aug 16;11:2377-2386. doi: 10.2147/DDDT.S143749. eCollection 2017.
A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation.
胃饥饿素受体激动剂对饮食诱导便秘的大鼠是一种有效的促结肠动力药。
Neurogastroenterol Motil. 2015 May;27(5):610-7. doi: 10.1111/nmo.12517. Epub 2015 Jan 19.
4
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats.内源性大麻素CB1和CB2受体对清醒大鼠中胃饥饿素诱导的食物摄入的自发和剪接变体的差异调节
Nutrition. 2015 Jan;31(1):230-5. doi: 10.1016/j.nut.2014.06.008. Epub 2014 Jul 5.
5
Peptide YY, neuropeptide Y and corticotrophin-releasing factor modulate gastrointestinal motility and food intake during acute stress.肽YY、神经肽Y和促肾上腺皮质激素释放因子在急性应激期间调节胃肠蠕动和食物摄入。
Neurogastroenterol Motil. 2014 Nov;26(11):1605-14. doi: 10.1111/nmo.12428. Epub 2014 Sep 19.
6
From endocrine to rheumatism: do gut hormones play roles in rheumatoid arthritis?从内分泌到风湿：肠道激素在类风湿关节炎中发挥作用？
Rheumatology (Oxford). 2014 Feb;53(2):205-12. doi: 10.1093/rheumatology/ket255. Epub 2013 Jul 23.
7
Central orexin-A increases colonic motility in conscious rats.中枢食欲素-A 增加清醒大鼠结肠蠕动。
Neurosci Lett. 2011 Jul 8;498(2):143-6. doi: 10.1016/j.neulet.2011.04.078. Epub 2011 May 6.
8
Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans.胃饥饿素对糖尿病动物和人类摄食行为和胃肠动力的调节作用。
J Chin Med Assoc. 2010 May;73(5):225-9. doi: 10.1016/S1726-4901(10)70048-4.
9
Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats.胃饥饿素和去酰基胃饥饿素对大鼠腰骶排便中枢的对比作用及对结肠直肠运动的调节。
Neurogastroenterol Motil. 2010 Oct;22(10):1124-31. doi: 10.1111/j.1365-2982.2010.01553.x. Epub 2010 Jun 24.
10
A novel simultaneous measurement method to assess the influence of intracerebroventricular obestatin on colonic motility and secretion in conscious rats.一种评估脑室内肥胖素对清醒大鼠结肠运动和分泌影响的新的同步测量方法。
Peptides. 2010 Jun;31(6):1113-7. doi: 10.1016/j.peptides.2010.03.024. Epub 2010 Mar 23.