Robertson Julia, Dalton James, Wiles Siouxsie, Gizdavic-Nikolaidis Marija, Swift Simon
Department of Molecular Medicine and Pathology, University of Auckland , Auckland , New Zealand.
Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
PeerJ. 2016 Dec 20;4:e2795. doi: 10.7717/peerj.2795. eCollection 2016.
Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis (TB), relying instead on personal protective equipment, such as facemasks, to reduce nosocomial transmission of the disease. Facemasks impregnated with an antimicrobial agent may be a cost-effective way of adding an extra level of protection against the spread of TB by reducing the risk of disease transmission. Conducting polymers, such as polyaniline (PANI), and their functionalised derivatives are a novel class of antimicrobial agents with potential as non-leaching additives to provide contamination resistant surfaces. We have investigated the antimicrobial action of PANI and a functionalised derivative, poly-3-aminobenzoic acid (P3ABA), against mycobacteria and have determined the optimal treatment time and concentration to achieve significant knockdown of and on an agar surface. Results indicated that P3ABA is a potential candidate for use as an anti-tuberculoid agent in facemasks to reduce TB transmission.
结核病被认为是全球主要死因之一。超过95%的病例和死亡发生在低收入和中等收入国家。在资源有限的国家，医院往往缺乏管理和隔离传染性肺结核（TB）患者的足够设施，而是依靠个人防护设备，如口罩，来减少该病的医院内传播。浸渍有抗菌剂的口罩可能是一种经济有效的方法，通过降低疾病传播风险来增加一层额外的防结核病传播保护。导电聚合物，如聚苯胺（PANI）及其功能化衍生物，是一类新型抗菌剂，有潜力作为无浸出添加剂以提供抗污染表面。我们研究了聚苯胺和一种功能化衍生物聚3-氨基苯甲酸（P3ABA）对分枝杆菌的抗菌作用，并确定了在琼脂表面实现对[具体细菌名称]和[具体细菌名称]显著抑制的最佳处理时间和浓度。结果表明，P3ABA有潜力作为口罩中的抗结核剂以减少结核病传播。
