孕期巨细胞病毒检测
Testing for Cytomegalovirus in Pregnancy.
作者信息
Saldan Alda, Forner Gabriella, Mengoli Carlo, Gussetti Nadia, Palù Giorgio, Abate Davide
机构信息
Department of Molecular Medicine, University of Padua, Padua, Italy.
Padua Reference Center for Infections in Pregnancy, Padua General Hospital, Padua, Italy.
出版信息
J Clin Microbiol. 2017 Mar;55(3):693-702. doi: 10.1128/JCM.01868-16. Epub 2016 Dec 28.
Abstract
Congenital cytomegalovirus (CMV) infection represents a relevant cause of deafness and neurological damage in newborns. Intrauterine CMV transmission might result after primary or nonprimary infections, though at different rates (30% versus 0.2%, respectively). At present, a prenatal diagnosis of CMV infection is based mainly on maternal serology, the detection of CMV-DNA in amniotic fluid and fetal blood, and ultrasound (US) and magnetic resonance imaging (MRI). Recent evidences suggest that congenital CMV infection may be an immune-mediated disease and that evaluation of humoral and especially T-cell immunities may improve the overall prenatal diagnosis. This review summarizes the most recent advancements in the diagnosis of maternal and prenatal CMV infections.
摘要
先天性巨细胞病毒（CMV）感染是新生儿耳聋和神经损伤的一个重要原因。宫内CMV传播可能发生在原发性或非原发性感染之后，不过发生率不同（分别为30%和0.2%）。目前，CMV感染的产前诊断主要基于母体血清学、羊水和胎儿血液中CMV-DNA的检测以及超声（US）和磁共振成像（MRI）。最近的证据表明，先天性CMV感染可能是一种免疫介导的疾病，评估体液免疫尤其是T细胞免疫可能会改善整体产前诊断。本综述总结了母体和产前CMV感染诊断方面的最新进展。
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